Monocyte‐Derived Macrophages Induce Alveolar Macrophages Death via TNF‐α in Acute Lung Injury

Acute lung injury (ALI) and its subsequent progression to acute respiratory distress syndrome (ARDS) are severe respiratory conditions. They are marked by rapid lung function deterioration and extensive pulmonary inflammation, often resulting in critical patient outcomes. Alveolar macrophages (AMs) and monocyte‐derived macrophages (MDMs) are two distinct subsets of lung macrophages present in the alveoli during ALI. Both are critical mediators of pulmonary inflammation. Our study examined the interplay between AMs and MDMs in the inflammatory environment of ALI/ARDS.

• Publication year

  2024

• Venue

  Immunity, Inflammation and Disease

• Publication date

  2024-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/iid3.70081PMID 39660881PMCID 11632899
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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