The role of insulin-like growth factor-I in neuroendocrine function and the consequent effects on sexual maturation: inferences from animal models.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Reproductive Biology

• Publication date

  2003-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 14666141
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Growth Hormone Insensitivity (Laron Syndrome)

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• Puberty is delayed in male growth hormone receptor gene-disrupted mice.

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• GH as a co-gonadotropin: the relevance of correlative changes in GH secretion and reproductive state.

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• Growth hormone is required for ovarian follicular growth.

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• Growth hormone and fertility in oMt1a-oGH transgenic mice.

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• Testicular endocrine function in GH receptor gene disrupted mice.

  2001cited by this paper
• Granulosa cell proliferation is impaired in the Igf1 null ovary.

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• Pituitary hormone gene expression and secretion in human growth hormone-releasing hormone transgenic mice: focus on lactotroph function.

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• Importance of the IGF system in early folliculogenesis.

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• The essential role of IGF-I: lessons from the long-term study and treatment of children and adults with Laron syndrome.

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• Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary.

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• Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice.

  1999cited by this paper
• Lack of effects of recombinant human GH on spermatogenesis in the adult cynomolgus monkey (Macaca fascicularis).

  1999cited by this paper
• IGF-I treatment increases motility and improves morphology of immature spermatozoa in the GH-deficient dwarf (dw/dw) rat.

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• Effects of Growth Hormone Replacement Therapy on IGF-Related Parameters and on the Pituitary-Gonadal Axis in GH-Deficient Males

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• Expression of mouse ovarian insulin growth factor system components during follicular development and atresia.

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• Expression of Mouse Ovarian Insulin Growth Factor System Components During Follicular Development and Atresia* * This work was supported by NIH Grant HD-24565 (to J.M.H.) and an NIH fellowship (to S.A.W).

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• The mouse intraovarian insulin-like growth factor I system: departures from the rat paradigm.

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• Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility

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• Insulin-like growth factor I regulates gonadotropin responsiveness in the murine ovary.

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• Impaired sperm characteristics in postpubertal growth-hormone-deficient dwarf (dw/dw) rats.

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  1996cited by this paper
• Effects of an Igf1 gene null mutation on mouse reproduction.

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• Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty.

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• Growth hormone and reproduction.

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• Rescue of pregnancy and maintenance of corpora lutea in infertile transgenic mice expressing an ovine metallothionein 1a-ovine growth hormone fusion gene.

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• Infertility in transgenic mice overexpressing the bovine growth hormone gene: disruption of the neuroendocrine control of prolactin secretion during pregnancy.

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• Cytochemical detection of gonadotropin-releasing hormone-binding sites on rat pituitary cells with luteinizing hormone, follicle-stimulating hormone, and growth hormone antigens during diestrous up-regulation.

  1994cited by this paper
• Recombinant growth hormone and insulin-like growth factor I do not alter gonadotrophin stimulation of the baboon testis in vivo.

  1994cited by this paper
• Cells that express luteinizing hormone (LH) and follicle-stimulating hormone (FSH) beta-subunit messenger ribonucleic acids during the estrous cycle: the major contributors contain LH beta, FSH beta, and/or growth hormone.

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• Neuroendocrine and Reproductive Consequences of Overexpression of Growth Hormone in Transgenic Mice

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• Effects of age and endogenously secreted human growth hormone on the regulation of gonadotropin secretion in female and male transgenic mice expressing the human growth hormone gene.

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• Expression and regulation of insulin-like growth factor-binding protein-1, -2, -3, and -4 messenger ribonucleic acids in purified rat Leydig cells and their biological effects.

  1993cited by this paper
• Ultrastructural colocalization of growth hormone binding protein and pituitary hormones in adenohypophyseal cells of the rat.

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• Gonadotropin secretion, synthesis, and gene expression in human growth hormone transgenic mice and in Ames dwarf mice.

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• Anatomy of the human ovarian insulin-like growth factor system.

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• Gonadotropin secretion, synthesis, and gene expression in two types of bovine growth hormone transgenic mice.

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• Induction of endogenous insulin-like growth factor-I secretion alters the hypothalamic-pituitary-testicular function in growth hormone-deficient adult dwarf mice.

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• Cotreatment with growth hormone for induction of spermatogenesis in patients with hypogonadotropic hypogonadism

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• Neuroendocrine function in adult female transgenic mice expressing the human growth hormone gene.

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• Human growth hormone enhances progesterone production by human luteal cells in vitro: evidence of a synergistic effect with human chorionic gonadotropin.

  1992cited by this paper
• Growth hormone secretory capacity and serum insulin-like growth factor I levels in primary infertile, anovulatory women with regular menses.

  1992cited by this paper
• Insulin-like growth factor-I (IGF-I) may not be essential for ovarian follicular development: evidence from IGF-I deficiency.

  1992cited by this paper
• Transgenic female mice with high human growth hormone levels are fertile and capable of normal lactation without having been pregnant.

  1992cited by this paper
• Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue.

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• Regulation of testicular insulin-like growth factor-I in pubertal growth hormone-deficient male rats.

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  1991cited by this paper
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• Independent control of the production of insulin-like growth factor I and its binding protein by cultured testicular cells.

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  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1986cited by this paper
• Growth hormone enhances follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells.

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  1984cited by this paper
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  1983cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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  1980cited by this paper
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  1978cited by this paper
• The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

  1978cited by this paper
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  1977cited by this paper
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  1972cited by this paper
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  1970cited by this paper
• HUMAN GROWTH HORMONE

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• Lactogenic Activity of Mammalian Growth Hormones in vitro

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• Human growth hormone.

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• Printed in U.S.A. Copyright © 1998 by The Endocrine Society Effects of Growth Hormone, Activin, and Follistatin on the Development of Preantral Follicle from Immature Female Mice

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• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Differential Expression of Growth Hormone Messenger Ribonucleic Acid by Somatotropes and Gonadotropes in Male and Cycling Female Rats*

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