Uncovering the hidden RNA virus diversity in Lake Nam Co: Evolutionary insights from an extreme high-altitude environment

Lilin Wu,Yongqin Liu,Wenqing Shi,Tianyi Chang,Pengfei Liu,Keshao Liu,Yong He,Zhaorong Li,Mang Shi,Nianzhi Jiao,Andrew S. Lang,Xiyang Dong,Qiang Zheng

Published 2025 in Proceedings of the National Academy of Sciences of the United States of America

ABSTRACT

Significance This study unveils the hidden diversity and complexity of RNA viruses in the high-altitude ecosystem of Lake Nam Co, significantly expanding the known RNA virome. The discovery of novel viral clades, expanded potential host ranges, and unique evolutionary adaptations emphasize the importance of exploring extreme environments to uncover viral diversity and evolutionary pathways. Our findings offer critical insights into viral evolution, host–virus interactions, and the ecological roles of RNA viruses, particularly in the context of climate change and environmental resilience.

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REFERENCES

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