Genome-Wide Association Study Pinpoints Novel Candidate Genes Associated with the Gestation Length of the First Parity in French Large White Sows

Simple Summary In modern pig production systems, the reproductive performance of sows significantly influences the economic efficiency of practical pig farming. Gestation length, a heritable reproductive trait, is closely linked to sow productivity, highlighting the importance of identifying single nucleotide polymorphisms (SNPs) and genes associated with this trait. In this study, we performed a genome-wide association analysis (GWAS) using imputed whole-genome sequence data to investigate gestation length in a large cohort of French Large White sows. The heritability of gestation length was estimated to be within the range of 0.22 and 0.26. Our analysis identified two novel quantitative trait loci (QTLs) located on chromosome 5 (QTL-1: 15.29–15.39 Mb and QTL-2: 12.86–12.94 Mb) and three promising candidate genes: TROAP, RFX4, and ADCY6. These findings enhance our understanding of the genetic architecture underlying gestation length in pigs and may provide valuable insights for improving reproductive performance through genomic selection.

• Publication year

  2025

• Venue

  Animals

• Publication date

  2025-02-01

• Fields of study

  Agricultural and Food Sciences, Medicine

• Identifiers
  DOI 10.3390/ani15030447PMID 39943217PMCID 11815982
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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