A wireless, 60-channel, AI-enabled neurostimulation platform

Objective Closed-loop neuromodulatory therapies require devices that can both decode ongoing brain states and deliver multi-site stimulation. Methods We describe the Smart Neurostimulation System (SNS), a cranially mounted implant with 60 configurable recording/stimulation channels, inductive power, and onboard spectral-feature classification. In three freely-moving sheep we streamed local-field potentials and conducted two parameter sweep experiments. Results Cross-validated movement classifiers achieved an average AUC > 0.95. Increasing stimulation amplitude and frequency produced post-stimulation elevations in α-band (8-12 Hz) and γ-band (78-82 Hz) power at most target locations. Conclusion The SNS unifies high-density sensing, real-time brain state decoding, and programmable closed-loop stimulation in a single device, demonstrating behavioral-state prediction and parameter-dependent neuromodulation in vivo. Significance These findings establish a preclinical foundation for biomarker-guided stimulation targeting distributed cortical networks underlying memory and cognition. Highlights Wireless 60-channel implant enables simultaneous sensing and stimulation vine study demonstrates reliable classification of movement and stimulation-related modulation of spectral activity The SNS represents a platform for biomarker-guided neuromodulation therapies

• Publication year

  2025

• Venue

  bioRxiv

• Publication date

  2025-08-05

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1101/2025.02.04.635298PMID 41429310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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