The effect of radiation dose to the brain on early self-reported cognitive function in brain and head-and-neck cancer patients

F. Vaassen,D. Hofstede,C. Zegers,J. Dijkstra,A. Hoeben,M. Anten,R. Houben,F.J.P. Hoebers,I. Compter,Wouter van Elmpt,D. Eekers

Published 2025 in Clinical and Translational Radiation Oncology

ABSTRACT

Highlights • Self-perceived cognitive decline after RT is important for brain and HN patients.• There is a dose–effect relationship with cognitive decline for brain structures.• Lower age, chemotherapy and higher baseline score are relevant parameters.• Brain mean dose > 3 Gy is related to cognitive deterioration.

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