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Mitochondrial potassium channels: New properties and functions.

Adam Szewczyk,P. Bednarczyk,Bogusz Kulawiak,Monika Żochowska,Barbara Kalenik,Joanna Lewandowska,Karolina Pytlak,Shur Gałecka,A. Wrzosek,P. Koprowski

Published 2025 in Biochimica et Biophysica Acta - Bioenergetics

ABSTRACT

Mitochondria are recently implicated in phenomena such as cytoprotection, cellular senescence, tumor metabolism, and inflammation. The basis of these processes relies on biochemical functions of mitochondria such as the synthesis of reactive oxygen species or biophysical properties such as the integrity of the inner mitochondrial membrane. The transport of potassium cations plays an important role in all these events. The K+ influx is mediated by potassium channels present in the inner mitochondrial membrane. In this article, we present an overview of our new findings on the properties of mitochondrial large-conductance calcium-activated and mitochondrial ATP-regulated potassium channels. This concerns the role of mitochondrial potassium channels in cellular senescence, and interactions with other mitochondrial proteins or small molecules such as quercetin, hemin, and hydrogen sulfide. We also discuss the prospects of research on potassium channels present in mitochondria.

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