SCIENCE@home

Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study

Qingzheng Wu,Bing Li,Yuepeng Wang,Yue Zhang,Qian Wang,Binqi Li,Wei Jing,Jing Yang,Yiming Mu

Published 2025 in Frontiers in Endocrinology

ABSTRACT

Background Recently, weight-adjusted-waist index (WWI), a new index for evaluating obesity, has been developed. This study aimed to examine the association between WWI and T2DM in Chinese urban adults. Method A total of 5,0978 eligible participants drawn from the prospective REACTION study (Cancer Risk Assessment in Chinese People with Diabetes) were included in this study. Participants were divided into 3 groups based on baseline WWI levels. Pearson correlation analysis and binary logistic regression analysis were conducted to explore the association of WWI with T2DM risk factors and with T2DM risk. Results The prevalence of obesity, central obesity and T2DM was 14.2%, 46.8% and 11.0% respectively, with a median age of 57 years. Logistic analysis showed that the WWI was significantly associated with the risk of T2DM. Compared to the lowest tertile of WWI (T1) serving as the reference group, the second tertile (T2) and the third tertile (T3) were associated with a 0.218-fold [1.218 (1.152, 1.288), P <0.001] and 0.286-fold [1.286 (1.212, 1.364), P <0.001] increase in the odds of developing T2DM respectively. After adjusting for all factors with the exception of the stratified variable, this association held true in age, sex, BMI, hypertension, and hyperlipidemia subgroup and was especially pronounced in those aged <60 years, BMI ≥24 kg/m2, and males, with interactions between WWI and age, sex, and BMI (P for interaction <0.05). Conclusion WWI was positively associated with T2DM in Chinese urban adults, especially in young and middle-aged males with BMI ≥24 kg/m2.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-46 of 46 references · Page 1 of 1

CITED BY