Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders

Eduardo Rivera-Mancilla,Usha M. Musterd-Bhaggoe,Dennis Schutter,Antoon J. van den Bogaerdt,Arnaud Vincent,Carlos M Villalón,A. Danser,A. Maassenvandenbrink

Published 2025 in British Journal of Pharmacology

ABSTRACT

Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and localization and expression in human isolated blood vessels.

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