Towards Sensitive and Cost‐Effective Chimerism Assays Using FABCASE: A Fast Approach for Estimating Assay Informativity

Chimerism monitoring is part of the standard of care for patients following an allogeneic hematopoietic stem cell transplantation. There has recently been a move towards sensitive, high‐throughput (next‐generation) sequencing analysis of biallelic markers for this purpose. Determining the number and properties of the markers to include in an assay to achieve reliable yet cost‐effective chimerism quantification is an underexposed but critical part of chimerism assay development, optimization, and validation.

• Publication year

  2025

• Venue

  International Journal of Laboratory Hematology

• Publication date

  2025-03-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/ijlh.14460PMID 40090321
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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