Multimodal feature‐guided diffusion model for low‐count PET image denoising

Gengjia Lin,Yuxi Jin,Zhenxing Huang,Zixiang Chen,Haizhou Liu,Chao Zhou,Xu Zhang,W. Fan,Na Zhang,Dong Liang,Peng Cao,Zhanli Hu

Published 2025 in Medical Physics (Lancaster)

ABSTRACT

To minimize radiation exposure while obtaining high‐quality Positron Emission Tomography (PET) images, various methods have been developed to derive standard‐count PET (SPET) images from low‐count PET (LPET) images. Although deep learning methods have enhanced LPET images, they rarely utilize the rich complementary information from MR images. Even when MR images are used, these methods typically employ early, intermediate, or late fusion strategies to merge features from different CNN streams, failing to fully exploit the complementary properties of multimodal fusion.

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