The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials

T. Nguyen,Jie Yu,V. Perkovic,M. Jardine,Kenneth W Mahaffey,Clara K. Chow,Clare Arnott,R. Lindley

Published 2025 in Journal of The American Geriatrics Society

ABSTRACT

Sodium‐glucose cotransporter 2 (SGLT2) inhibitors have been shown to improve renal and cardiovascular outcomes in patients with type 2 diabetes. Limited evidence exists about the efficacy and safety of SGLT2 inhibitors in patients with frailty.

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