Chemical synthesis of conjugation-ready tetrasaccharide repeating unit of Escherichia coli O50 O-antigen.

Escherichia coli is a rod-shaped Gram-negative bacterium notorious for provoking diverse human infections. In this study, we report the first total synthesis of tetrasaccharide repeating unit of the cell wall of Gram-negative bacteria Escherichia coli O50 augmented with aminoethyl linker, employing both linear [1+1+1+1] and one-pot [1+1+2] approaches, and later one providing the better yield. As an aminoethyl linker, it can be further utilized for biological purposes; the challenging cis (1 → 4)-β-glycosidic linkage between l-rhamnose and d-glucosamine is addressed here with high stereo control.

• Publication year

  2025

• Venue

  Carbohydrate Research

• Publication date

  2025-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.carres.2025.109485PMID 40228335
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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