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Therapeutic potential of microRNA in meniscal repair and regeneration.

G. Jacob,K. Shimomura,Hiroto Hanai,Taro Akimori,T. Ohori,Akira Tsujii,Yu Moriguchi,Norimasa Nakamura

Published 2025 in Knee (Oxford)

ABSTRACT

BACKGROUND Managing meniscal injuries is challenging due to the complex nature of the tissue and its limited healing capacity. MicroRNAs (miRNAs) are key regulators of cellular processes, making them promising candidates for therapeutic interventions aimed at enhancing meniscal repair. This study explores the potential role of miRNAs in meniscal healing. METHODS A comprehensive literature search was conducted in July 2024 using the PubMed (MEDLINE) and EMBASE databases, without any date restrictions. Relevant studies involving the use of miRNAs in meniscal injury or repair were identified, and a narrative review was performed. RESULTS The search yielded three in-vitro studies and one animal study, with no clinical studies found. The identified studies suggest that miRNAs may enhance meniscal healing by promoting angiogenesis and reducing inflammation. CONCLUSIONS This review underscores the emerging potential of miRNA-based therapies for meniscal repair and regeneration. While progress has been made in understanding the mechanisms of action, several challenges remain before clinical application, including safety concerns, the need for standardized protocols, and the development of clinical-grade miRNA products.

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