SCIENCE@home

New insight into intestinal toxicity accelerated by aged microplastics with triclosan: Inflammation regulation by gut microbiota-bile acid axis.

Dawu Lin,Xiangyu Chen,Xiaojun Lin,Chaonan Zhang,Taojie Liang,Li Zheng,Yanbin Xu,Lu Huang,Qingxia Qiao,Kairong Xiong

Published 2025 in Journal of Hazardous Materials

ABSTRACT

The combined toxic effects of microplastics (MPs) and their carried contaminants on organisms have been widely concerned; however, the health risks and its mechanism of "gut microbiota-host metabolism (bile acids, BA)" remain unknown. Herein, Xenopus tropicalis were exposured to aged polystyrene MPs carried triclosan (aPS+TCS) and single (a)PS-MPs & TCS, respectively. The bioaccumulation of TCS in the gut of X. tropicalis was significantly increased in aPS+TCS group, which was 89 % higher than that of PS+TCS group, causing more severe oxidative stress, inflammation and intestinal barrier disruption (leaky gut). The expressions of TNF-α, IL-6 and IL-10 in aPS+TCS group were enhanced by 276 % and 19 % and decreased by 81 %, respectively, compared to that in PS+TCS group. Moreover, co-exposure to aPS+TCS increased the number of Escherichia coli, and reduced levels of DCA and LCA (secondary BAs). Multiomics analysis further revealed that the intestinal toxicity of aPS+TCS to X. tropicalis was mainly influenced by the gut flora, BA metabolism and inflammation-related pathways. Co-exposure may exacerbate inflammation by increasing the blood levels of lipopolysaccharides and inhibiting secondary BA production, which are regulated by the gut microbiota-bile acid axis. This study provides new insights in the potential mechanisms of intestinal damage from pollutant-loaded aged MPs.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-54 of 54 references · Page 1 of 1

CITED BY

Showing 1-10 of 10 citing papers · Page 1 of 1