A New Model to Investigate the Action of Radiation and Cigarette Smoke on Head and Neck Cancer Cells

Simple Summary Smokers are at an increased risk of developing mucosal head and neck cancers. Moreover, they have worse oncological outcomes following treatment; the reasons for this are unknown. To address this, we developed a new experimental model investigating the effects of radiation and smoking on head and neck cancer cells. We found through that radiation and smoking separately altered cell behaviour, and when combined had a greater effect. Gene sequencing reflected the changes in cell behaviour after treatments. Our results show that this new experimental model is relevant in evaluating the combination of radiation and smoking on head and neck cancer cell behaviour.

• Publication year

  2025

• Venue

  Cancers

• Publication date

  2025-04-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.3390/cancers17081346PMID 40282522PMCID 12026225
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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