Coexistence of Tuberculous Lymphadenitis and Hodgkin Lymphoma: A Diagnostic Challenge

Hodgkin lymphoma (HL) and tuberculosis (TB) share overlapping clinical features, such as lymphadenopathy, fever, weight loss, and night sweats, which can complicate the diagnostic process, particularly in endemic regions. This case report describes a 10-year old boy with persistent cervical lymphadenopathy, initially diagnosed as tuberculous lymphadenitis based on fine-needle aspiration cytology (FNAC). The child was promptly started on anti-tubercular therapy (ATT), but his condition showed no improvement. Repeated biopsies ultimately revealed mixed cellularity HL, with the same lymph node testing positive for Mycobacterium tuberculosis, confirming a rare coexistence of both diseases. This case highlights the challenges clinicians face when both TB and HL are present, as the clinical symptoms may overlap. It also emphasizes the importance of considering malignancies as differential diagnoses in cases of persistent lymphadenopathy, even in TB-endemic regions.

• Publication year

  2025

• Venue

  Cureus

• Publication date

  2025-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.7759/cureus.82771PMID 40416277PMCID 12098736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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