Investigation of 15N-SABRE hyperpolarization at high pressures and in supercritical fluids.

Signal Amplification By Reversible Exchange (SABRE) is a parahydrogen-based hyperpolarization technique that can generate orders-of-magnitude larger signals than thermal spin polarization within a minute. However, this method is limited by the availability of parahydrogen to the solution. Previous work demonstrated SABRE-derived 1H hyperpolarization at pressures up to 200 bar and using liquid carbon dioxide as a solvent. Here, we extend this work to demonstrate heteronuclear (15N) SABRE hyperpolarization using conventional solvents with hydrogen pressures up to 400 bar as well as the possibility of using supercritical CO2 as the solvent. We demonstrate that in both modes, 15N hyperpolarization comparable to SABRE-SHEATH may be achieved, providing a route for future optimization efforts as well as scale-up. We also present first steps towards exploring SABRE hyperpolarization of 129Xe.

• Publication year

  2025

• Venue

  Journal of magnetic resonance (San Diego, Calif. 1997 : Print)

• Publication date

  2025-04-26

• Fields of study

  Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1016/j.jmr.2025.107876PMID 40288153
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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