SCIENCE@home

Pre-vascularized bioactive scaffold driven by bidirectional cellular communication enhances bone repair.

Xiaolong Shen,Ye Tian,Lei Wang,Leixin Wei,H. Zhong,Haoyi Wang

Published 2025 in Colloids and Surfaces B: Biointerfaces

ABSTRACT

Bone, characterized by its extensive vascularization, relies on angiogenesis as a fundamental prerequisite for successful regeneration. However, conventional bone implant materials often exhibit limitations such as insufficient vascularization, leading to cellular necrosis and delayed host tissue infiltration. To address these challenges, this study integrates 3D printing and photo-crosslinking technologies to develop a pre-vascularized bioactive scaffold driven by endothelial cells (ECs)/ bone marrow mesenchymal stem cells (BMSCs) bidirectional cellular communication, aiming to facilitate the rapid reconstruction of vascular and bone networks. The results demonstrate that the scaffold not only enhances the vascularization of ECs, but also activates BMP-2 and TGF-β signaling of BMSCs through EC-secreted growth factors, thus synergistically enhancing the osteogenic differentiation of BMSCs. In a rat femoral defect model, this bioactive pre-vascularized scaffold exhibited robust matrix deposition and osteoinductive capacity, offering a promising strategy to enhance bone regeneration and address bone defects.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-45 of 45 references · Page 1 of 1

CITED BY