Differential impact of microcystins MC-LR and [D-Leu1]MC-LR in different areas of the rat brain after chronic exposure: oxidative stress and antioxidant responses

Highlights • Injected MC isoform concentration varied by dose and brain region.• At 10 and 75 μg kg-1, the MC-LR accumulation rate was higher than the [D-Leu1]MC-LR.• Chronic MCs exposure caused dose/area-dependent mild oxidative stress (↑ROS, CAT activation).• With higher MC dose all brain regions exhibited elevated reactive species.

• Publication year

  2025

• Venue

  Current Research in Microbial Sciences

• Publication date

  2025-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.crmicr.2025.100401PMID 40487029PMCID 12143765
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Marine and freshwater toxins.

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