Post-thrombotic syndrome after early intervention in acute lower limb deep vein thrombosis: a retrospective cohort study

Background: Post-thrombotic syndrome (PTS) is a potential long-term complication of deep vein thrombosis (DVT), proven to significantly impact quality of life. This study aims to determine the incidence, clinical manifestations, and predictors of PTS following early intervention for acute lower limb DVT in a single tertiary center. Methods: This retrospective study included patients with acute iliofemoral DVT who underwent thrombectomy and thrombolysis. Patients were categorized based on PTS presence, defined by a five or higher Villalta score. Results: Among 113 patients, 29.2% developed PTS (23.0% mild, 6.2% moderate). At 6 months post-intervention (PI), the PTS group had significantly higher median Villalta scores (9 vs. 3; P < 0.001) and Venous Clinical Severity Scores (6 vs. 3; P < 0.001) than the non-PTS group. The PTS group also showed poorer symptom improvement and occlusion outcomes on imaging (P < 0.001). PTS predictors included age ≥60 years, symptom onset time ≥8days, and lower limb circumference difference <1.5 cm at 1-month PI. Compared to thrombectomy, thrombolysis was not an independent factor for PTS (P > 0.05). Conclusions: PTS is common in patients undergoing early intervention for acute DVT via thrombectomy or thrombolysis. Its presence in the midterm period is associated with poorer symptom improvement and occlusion outcomes. The predictors included older age, prolonged pre-intervention symptoms, and poor lower limb circumference improvement. Physicians should monitor midterm PI patients to identify and enhance symptom improvement, especially those with risk factors.

• Publication year

  2024

• Venue

  International Journal of Surgery Open

• Publication date

  2024-11-11

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1097/IO9.0000000000000234
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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