Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Development

• Publication date

  1998-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 9735354
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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  1996cited by this paper
• P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.

  1996cited by this paper
• Gene expression in the limbless mutant: polarized gene expression in the absence of Shh and an AER.

  1996cited by this paper
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• Dorsal cell fate specified by chick Lmx1 during vertebrate limb development

  1996influential reference
• The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions.

  1996cited by this paper
• The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation.

  1996cited by this paper
• Visualization of Gene Expression in Living Adult Drosophila

  1996cited by this paper
• Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.

  1996cited by this paper
• A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis.

  1996cited by this paper
• Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc.

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• Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity.

  1996influential reference
• P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.

  1995cited by this paper
• Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning.

  1995cited by this paper
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• Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing.

  1995cited by this paper
• Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

  1995cited by this paper
• Vertebrate limb development.

  1995influential reference
• Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila.

  1995cited by this paper
• fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.

  1994influential reference
• The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila.

  1994cited by this paper
• Vertebrate limb development.

  1994cited by this paper
• Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis.

  1994cited by this paper
• LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells.

  1993cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993cited by this paper
• Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions.

  1993cited by this paper
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  1993cited by this paper
• Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes.

  1993influential reference
• Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila.

  1993cited by this paper
• The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm.

  1993cited by this paper
• Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.

  1992cited by this paper
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  1992cited by this paper
• Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development.

  1992cited by this paper
• Two distal-less related homeobox-containing genes expressed in regeneration blastemas of the newt.

  1992cited by this paper
• Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.

  1992cited by this paper
• Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations

  1992cited by this paper
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  1992cited by this paper
• Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

  1991cited by this paper
• Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

  1991cited by this paper
• Specification of limb development in the Drosophila embryo by positional cues from segmentation genes

  1990cited by this paper
• Distal-less encodes a homoeodomain protein required for limb development in Drosophila

  1989cited by this paper
• Hox‐7, a mouse homeobox gene with a novel pattern of expression during embryogenesis.

  1989cited by this paper
• Development of the apical ectodermal ridge in the chick wing bud.

  1984cited by this paper
• Studies on a limbless mutant in the chick embryo.

  1983cited by this paper
• Genetic transformation of Drosophila with transposable element vectors.

  1982cited by this paper
• Limbless: a new genetic mutant in the chick.

  1979cited by this paper
• Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila.

  1976cited by this paper
• Developmental compartmentalisation of the wing disk of Drosophila.

  1973cited by this paper
• Positional Information in Chick Limb Morphogenesis

  1973cited by this paper
• Lakes Beneath the Antarctic Ice Sheet

  1973cited by this paper
• Studies on limb morphogenesis. VI. Experiments with early stages of the polydactylous mutant Eudiplopodia.

  1971cited by this paper
• Cell lineage relationships in the imaginal wing disc of Drosophila melanogaster.

  1970cited by this paper
• STUDIES ON LIMB MORPHOGENESIS. II. EXPERIMENTS WITH THE POLYDACTYLOUS MUTANT EUDIPLOPODIA.

  1964cited by this paper

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