Sodium Iodide-Promoted Construction of Fully Substituted 4-Sulfenyl-5-aminopyrazole Derivatives.

Transition-metal-free synthesis of diversely substituted 4-sulfenyl-5-aminopyrazoles was developed under mild conditions through NaI-mediated three-component reaction of β-ketonitriles, disulfides, and hydrazines. The pyrazole products were constructed via consecutive cleavage of C-O and S-S bonds and recombination of C-N and C-S bonds. The methodology features broad substrate scope, mild transition-metal-free conditions, and easy manipulation.

• Publication year

  2025

• Venue

  Journal of Organic Chemistry

• Publication date

  2025-05-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.joc.5c00667PMID 40399243
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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