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Calcineurin controls the cytokinesis machinery during thermal stress in Cryptococcus deneoformans

V. Yadav,Anna Floyd Averette,R. Upadhya,J. Heitman

Published 2025 in Proceedings of the National Academy of Sciences of the United States of America

ABSTRACT

Significance Cellular responses to external stress conditions involve activation of signaling cascades, which act via effectors to govern key cellular processes. One such signaling cascade involves the phosphatase calcineurin, the conserved target of cyclosporin A and FK506 that governs myriad cellular functions through its substrates. In human fungal pathogens, calcineurin is critical for pathogenicity. Here, we employed a genetic screen to map the functional interactions of this signaling cascade and repeatedly identified mutations in components of a single protein complex, suggesting a focused downstream response. With genetic and biochemical approaches, we established that these proteins play a crucial role in cell division at high temperature enabling cell division and revealing broad avenues of research that could identify potential antifungal drug targets.

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