Can the co-localization of CD8+, PD-1, PD-L1 AND PD-L2 patterns provide guidance in clinical evolution of patients with head and neck cutaneous squamous cell carcinoma?

Gustavo Nunes Bento,André Bandiera de Oliveira Santos,L. Matos,William C. Faquin,Sara I. Pai,C. Cernea

Published 2025 in Brazilian Journal of Otorhinolaryngology

ABSTRACT

Highlights • The co-localization of PD-1/PD-L1 could be a promising tool for prognostic evaluation.• The first study to assess co-localization of CD8, PD1, PDL1, PDL2 in cSCC.• Notable presence of CD8+T-cell infiltration in cSCC, co-localizing with PD-L1/L2.

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