The Prognostic Value of Perioperative Factors on Biochemical Recurrence in Patients Undergoing Radical Prostatectomy

Introduction We aimed to assess the role of major perioperative risk factors (age, preoperative PSA values, body mass index, pathologic T-stage, resection status, and ISUP grade) in predicting biochemical recurrence (BCR) and survival after radical prostatectomy (RP) for prostate cancer (PC). Methods An analysis of the prospective cohort of patients undergoing RP from 2013 to 2023 at our center was performed. Patients who received neoadjuvant or adjuvant therapies for PC or those with PSA persistence after RP were excluded. A Cox regression analysis was undertaken to evaluate the effect of major perioperative risk factors on the time to BCR. The role of the EAU BCR risk stratification on survival was also assessed. For all analyses, hazard ratios (HRs) with the corresponding 95% confidence intervals (CIs) were estimated. Results A total of 1539 patients underwent RP for localized PC. At a median follow-up of 39 months (IQR: 25–60) from RP, 393 (26%) patients developed BCR. Of them, 266 (68%) were classified as EAU BCR high risk and 127 (32%) as EAU BCR low risk. In the multivariate Cox regression analysis, locally advanced PC (HR: 1.5, 95% CI: 1.2–1.9, p<0.001), positive surgical margins (HR: 1.4, 95% CI: 1.1–1.7, p=0.01), as well as ISUP grade 3 (HR: 2.4, 95% CI: 1.5–3.6, p<0.001) and 4 (HR: 2.4, 95% CI: 1.5–3.7, p<0.001) were associated with worse time to BCR. Overall, 16 (1%) patients died. Of them, 13 (81%) were classified as EAU BCR high risk and 3 (19%) as EAU BCR low risk (p<0.001). In the univariate Cox regression analysis, patients with EAU BCR high risk presented worse overall survival (HR: 4.9, 95% CI: 1.4–17, p=0.014). Conclusion Locally advanced PC, positive surgical margins, and worse ISUP grade are independent risk factors for BCR. Accordingly, patients at BCR high-risk based on the EAU risk stratification present worse overall survival.

• Publication year

  2025

• Venue

  Research and Reports in Urology

• Publication date

  2025-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2147/RRU.S500506PMID 40453579PMCID 12126099
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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