Exploring the potential mechanism of tofacitinib therapy for ankylosing spondylitis through gut microbiome and plasma metabolomics

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Clinical Rheumatology

• Publication date

  2025-05-29

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s10067-025-07467-zPMID 40439987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression

  2025cited by this paper
• Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum by Digital Chromoendoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without Having Inflammatory Bowel Disease

  2024cited by this paper
• 13C-Stable isotope resolved metabolomics uncovers dynamic biochemical landscape of gut microbiome-host organ communications in mice

  2024cited by this paper
• 6-formylindolo[3, 2-b]carbazole alters gut microbiota and prevents the progression of ankylosing spondylitis in mice.

  2024cited by this paper
• Role of the Gut Microbiota in Osteoarthritis, Rheumatoid Arthritis, and Spondylarthritis: An Update on the Gut–Joint Axis

  2024cited by this paper
• Identification of a Novel Gene Expression Signature Associated with Amino Acid Metabolism (AAM) in Ankylosing Spondylitis (AS)

  2024cited by this paper
• [Faecal microbiota study reveals specific dysbiosis in spondyloarthritis according to subtype, disease activity and treatment].

  2024cited by this paper
• Alterations in the gut virome in patients with ankylosing spondylitis

  2023cited by this paper
• Seronegative spondyloarthropathy-associated inflammatory bowel disease

  2023cited by this paper
• Shared and Distinct Gut Microbiota in Spondyloarthritis, Acute Anterior Uveitis, and Crohn's Disease

  2023cited by this paper
• Gas Chromatography–Mass Spectrometry Reveals Stage-Specific Metabolic Signatures of Ankylosing Spondylitis

  2023cited by this paper
• Differential gut microbiome in spondyloarthritis patients associated to Blastocystis colonization

  2023cited by this paper
• Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis

  2023cited by this paper
• Patients with ankylosing spondylitis have high risk of irritable bowel syndrome: a long-term nationwide population-based cohort study

  2022cited by this paper
• Discovery of fecal microbial signatures in patients with ankylosing spondylitis

  2022cited by this paper
• Untargeted Lipidomics Reveals Characteristic Biomarkers in Patients with Ankylosing Spondylitis Disease

  2022cited by this paper
• ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update

  2022cited by this paper
• Role of the microbiome and its metabolites in ankylosing spondylitis

  2022cited by this paper
• Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

  2022cited by this paper
• A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production.

  2022cited by this paper
• HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway

  2022cited by this paper
• Treatment of axial spondyloarthritis: an update

  2022cited by this paper
• Tofacitinib for the treatment of active ankylosing spondylitis in adults

  2022cited by this paper
• Indole-3-Acetic Acid Alters Intestinal Microbiota and Alleviates Ankylosing Spondylitis in Mice

  2022cited by this paper
• Ankylosing spondylitis risk factors: a systematic literature review

  2021cited by this paper
• Gut microbiota changes in inflammatory bowel diseases and ankylosing spondilytis.

  2021cited by this paper
• Serum Metabolomics Signatures Associated With Ankylosing Spondylitis and TNF Inhibitor Therapy

  2021cited by this paper
• The Interplay between Immune System and Microbiota in Inflammatory Bowel Disease: A Narrative Review

  2021cited by this paper
• Characteristics of the intestinal microbiome in ankylosing spondylitis

  2021cited by this paper
• Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders

  2021cited by this paper
• Tofacitinib Ameliorates Lupus Through Suppression of T Cell Activation Mediated by TGF-Beta Type I Receptor

  2021cited by this paper
• Intestinal Microbial Metabolites in Ankylosing Spondylitis

  2021cited by this paper
• Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

  2021cited by this paper
• Editorial: Advances in Pathogenesis, Etiology, and Therapies for Ankylosing Spondylitis

  2021cited by this paper
• Gut microbiota and metabolic syndrome

  2020cited by this paper
• The Association of Fecal Microbiota in Ankylosing Spondylitis Cases with C-Reactive Protein and Erythrocyte Sedimentation Rate

  2020cited by this paper
• Determinants of the Physician Global Assessment of Disease Activity and Influence of Contextual Factors in Early Axial Spondyloarthritis

  2020cited by this paper
• Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

  2020cited by this paper
• Dynamic changes in gut microbiota under the influence of smoking and TNF-α-blocker in patients with ankylosing spondylitis

  2020cited by this paper
• Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

  2020cited by this paper
• Variations in gut microbial profiles in ankylosing spondylitis: disease phenotype-related dysbiosis.

  2019cited by this paper
• A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin

  2019cited by this paper
• Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner

  2018cited by this paper
• Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

  2018cited by this paper
• Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate

  2018cited by this paper
• Ileocolonoscopic findings in patients with ankylosing spondylitis: a single center retrospective study

  2017cited by this paper
• Intestinal Metabolites Are Profoundly Altered in the Context of HLA–B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis

  2017cited by this paper
• Amino-acid transporters in T-cell activation and differentiation

  2017cited by this paper
• Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis

  2017cited by this paper
• Subclinical gut inflammation in ankylosing spondylitis

  2016cited by this paper
• A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

  2016cited by this paper
• Plasma, urine and ligament tissue metabolite profiling reveals potential biomarkers of ankylosing spondylitis using NMR-based metabolic profiles

  2016cited by this paper
• Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease

  2016cited by this paper
• Impact of the gut microbiota on inflammation, obesity, and metabolic disease

  2016cited by this paper
• Reduced Histone H3 Acetylation in CD4+ T Lymphocytes: Potential Mechanism of Latent Autoimmune Diabetes in Adults

  2015cited by this paper
• The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

  2014cited by this paper
• Gut microbiota and metabolic syndrome.

  2014cited by this paper
• Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine.

  2009cited by this paper
• Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis.

  2008cited by this paper
• Assessments in ankylosing spondylitis.

  2007cited by this paper
• Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis

  2005cited by this paper
• Publisher's Note

  2003cited by this paper
• PALLIATIVE CARE SECTION Original Research Article Measurement of Affective and Activity Pain Interference Using the Brief Pain Inventory (BPI): Cancer and Leukemia Group B 70903

  year unknowncited by this paper
• Extended Report

  year unknowncited by this paper

• Distinct gut microbiota profiles in acute vs. chronic sinusitis: potential biomarkers

  2025cites this paper
• The Gut-Joint Connection: Microbiome’s Role in Rheumatic Disease

  2025cites this paper