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Pharmacological exploration of natural 6-hydroxy flavone: A promising moiety.

H. Patil,Siddheshwar Parmeshwar Khule,Manish Gagrani,S. D. Pawar

Published 2025 in Fitoterapia

ABSTRACT

BACKGROUND 6-hydroxy Flavone (6-HF) is a naturally occurring biologically active flavonoid in Barleria Prionitis Linn. Plant Family Acanthaceae leaves. The 6-HF exhibits pharmacological activities like noncompetitive cytochrome P450 2C9 enzyme inhibitors, potent antioxidants, anti-inflammatory, antimicrobial, and anticancer effects. METHOD This article has been written by collecting detailed information from online databases such as research articles from various public domain sites, PubMed, ScienceDirect, Google Scholar, Web of Science, and Scopus. RESULTS A comprehensive review of the available data indicates that 6-HF can modulate key molecular processes involved in tracheal relaxation, inflammation, oxidative stress, and cellular differentiation. 6-HF has a potential anti-inflammatory impact by blocking important inflammatory pathways, a promising anxiolytic and neuroprotective effect by modifying Gamma-Aminobutyric Acid Type A(GABAA) receptor function, and a promising anticancer effect by causing apoptosis by activating p53, p21, and caspases. It suppresses the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, preventing the activation of pro-inflammatory genes. Also, 6-HF reduces oxidative stress by neutralizing reactive oxygen species (ROS) generated in mitochondria and other cellular organelles. Despite all activities, a detailed study is required to show the exact molecular pathway behind these activities, and investigating its pharmacokinetic characteristics, bioavailability, and potential toxicity will be critical for its development as a medicinal drug. This study aims to provide a comprehensive summary of the pharmacological properties of 6-HF, highlighting the need for further research to determine its therapeutic potential fully. CONCLUSION This review article briefly overviews chemistry, isolation, and pharmacological activity, along with some mechanisms.

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