Catalytic Diastereoselective Synthesis of Bicyclo[3.2.1]octanediones

The bicyclo[3.2.1]octanone and bicyclo[3.2.1]octanedione scaffolds, along with their derivatives, are ubiquitous in natural products and synthetic pharmaceuticals. However, the synthetic routes to access these scaffolds have been relatively underdeveloped. Herein, this study introduces a unique reaction between pent‐4‐ene‐1,3‐diones and vinyl diketones, which serves as a versatile platform for the efficient synthesis of a wide array of bicyclo[3.2.1]octanediones in good to excellent yields. Furthermore, this study method facilitates diverse downstream transformations of these products, underscoring the versatility and potential of diketone‐based chemistry in constructing complex molecules.

• Publication year

  2025

• Venue

  Advanced Synthesis & Catalysis

• Publication date

  2025-06-16

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1002/adsc.202500324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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