Key variables associated with gastroparesis in diabetes patients with gastroparesis-like symptoms

Abstract Background/aims Gastroparesis is a late complication of diabetes mellitus characterized by delayed gastric emptying and upper gastrointestinal symptoms. The disorder substantially impacts the quality of life, glycemic stability, nutrition and absorption of orally administered drugs. Since symptom severity is a poor predictor of gastric emptying status, the clinician has little to aid them in whom to refer for gastric emptying testing. In this study, we aim to identify clinical characteristics associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. Materials and methods Diabetes patients consecutively referred to Haukeland University Hospital for assessment of gastroparesis-like symptoms underwent gastric emptying scintigraphy, blood samples and questionnaires for assessing gastrointestinal symptoms (Gastrointestinal Symptom Rating Scale), neuroticism (Eysenck Personality Questionnaire-Short Form), and symptoms of anxiety and depression (Hospital Anxiety & Depression Scale). Results: Seventy-one patients were included in the study, of which 28 displayed delayed gastric emptying. Delayed gastric emptying was characterized by having type 1 diabetes, younger age, lower BMI, presence of other late complications including distal symmetric polyneuropathy and retinopathy, higher Hb1Ac levels and lower albumin and hemoglobin levels. Symptoms were not related to gastric emptying status. Conclusion We identified several clinical variables associated with delayed gastric emptying in diabetes patients with gastroparesis-like symptoms. These variables are commonly assessed during a medical consultation and may be used to aid the clinician in choosing who to refer for gastric emptying testing. Graphical Abstract

• Publication year

  2025

• Venue

  Scandinavian Journal of Gastroenterology

• Publication date

  2025-07-12

• Fields of study

  Medicine

• Identifiers
  DOI 10.1080/00365521.2025.2531038PMID 40650418
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reexamining Compliance with Gastric Emptying Scintigraphy Guidelines: An Updated Analysis of the Intersocietal Accreditation Commission Database

  2023cited by this paper
• The prevalence and risk factors of irritable bowel syndrome (PRIBS study) among adults in low‐ and middle‐income countries: A multicenter cross‐sectional study

  2023cited by this paper
• A cross-sectional study describing peripheral neuropathy in patients with symptoms of gastroparesis: associations with etiology, gastrointestinal symptoms, and gastric emptying

  2022cited by this paper
• Normal and disordered gastric emptying in diabetes: recent insights into (patho)physiology, management and impact on glycaemic control

  2022cited by this paper
• Gastroparesis Symptoms Associated with Intestinal Hypomotility: An Explorative Study Using Wireless Motility Capsule

  2021cited by this paper
• Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls

  2021cited by this paper
• Gastric function in diabetic gastroparesis assessed by ultrasound and scintigraphy

  2021cited by this paper
• Gastric Emptying Abnormalities in Diabetes Mellitus.

  2021cited by this paper
• Factors that contribute to the impairment of quality of life in gastroparesis

  2021cited by this paper
• Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: Relationship with etiology, gastric emptying, and symptom severity

  2020cited by this paper
• The Use of Visceral Proteins as Nutrition Markers: An ASPEN Position Paper.

  2020cited by this paper
• Gastrointestinal symptoms and cardiac vagal tone in type 1 diabetes correlates with gut transit times and motility index

  2020cited by this paper
• Delayed Gastric Emptying Associates With Diabetic Complications in Diabetic Patients With Symptoms of Gastroparesis.

  2019cited by this paper
• Wireless motility capsule compared with scintigraphy in the assessment of diabetic gastroparesis

  2019cited by this paper
• Is gastroparesis a gastric disease?

  2019cited by this paper
• DIABETIC GASTROPARESIS.

  2019cited by this paper
• A longitudinal study on patients with diabetes and symptoms of gastroparesis - associations with impaired quality of life and increased depressive and anxiety symptoms.

  2018cited by this paper
• Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis

  2018cited by this paper
• Gastroparesis

  2018cited by this paper
• Anemia, bilirubin, and cardiovascular autonomic neuropathy in patients with type 2 diabetes

  2017cited by this paper
• Relationship Between Control of Glycemia and Gastric Emptying Disturbances in Diabetes Mellitus.

  2016cited by this paper
• Delayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes Mellitus.

  2015cited by this paper
• Gastric emptying and glycaemia in health and diabetes mellitus

  2015cited by this paper
• Counseling on lifestyle habits in the United States and Sweden: a report comparing primary care health professionals’ perspectives on lifestyle counseling in terms of scope, importance and competence

  2014cited by this paper
• Risk of Gastroparesis in Subjects With Type 1 and 2 Diabetes in the General Population

  2012cited by this paper
• Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis.

  2011cited by this paper
• Safety and efficacy of ghrelin agonist TZP‐101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo‐controlled study

  2010cited by this paper
• Health and Quality of Life Outcomes

  2008cited by this paper
• Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine

  2008cited by this paper
• The validity of the Hospital Anxiety and Depression Scale. An updated literature review.

  2002cited by this paper
• Predictors of delayed gastric emptying in diabetes.

  2001cited by this paper
• Demography, Clinical Characteristics, Psychological and Abuse Profiles, Treatment, and Long-Term Follow-up of Patients with Gastroparesis

  1998cited by this paper
• Psychological factors and somatic symptoms in functional dyspepsia. A comparison with duodenal ulcer and healthy controls.

  1994cited by this paper

• No citing papers are available for this paper.