Narrative review: Isolated nocturnal hypertension - A frosted glass.

The following article is a narrative review on isolated nocturnal hypertension, conducted up to July 2024, with a search for primary and secondary articles in MEDLINE, LILACS, and gray literature. This review highlights aspects related to its current definition, epidemiology, and associated populations and risk factors, as well as specifics regarding its diagnosis, prognostic importance for target organ damage and cardiovascular events/mortality, and potential treatments. This condition has particular aspects and, although it is not very common in the general population, it reaches high prevalence in some at-risk populations. To date, there is much debate and many issues to investigate regarding diagnostic aspects, as well as its heterogeneity and clinical significance, which indicate different prognoses. Therapeutic aspects are even more a matter of debate, necessitating future research.

• Publication year

  2025

• Venue

  Hipertensión y Riesgo Vascular

• Publication date

  2025-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.hipert.2025.02.002PMID 40651936
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 2024 Latin American Society of Hypertension guidelines on the management of arterial hypertension and related comorbidities in Latin America.

  2024cited by this paper
• Circulating angiotensin-(1–7) is decreased in patients with isolated nocturnal hypertension

  2024cited by this paper
• Ambulatory blood pressure parameters and their association with albuminuria in adolescents with type 1 diabetes mellitus

  2024cited by this paper
• PREVALENCE AND CHARACTERISTICS OF ISOLATED NOCTURNAL HYPERTENSION IN TREATED PATIENTS

  2024cited by this paper
• HIGH PREVALENCES OF NOCTURNAL HYPERTENSION AND ISOLATED NOCTURNAL HYPERTENSION IN LONG-STANDING VIRALLY SUPPRESSED PEOPLE LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS

  2024cited by this paper
• 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH).

  2023cited by this paper
• Sleep-related factors associated with masked hypertension: the Nagahama study

  2023cited by this paper
• Masked Hypertension in Pediatric Heart Transplant Recipients

  2023cited by this paper
• Prevalence and Characteristics of Isolated Nocturnal Hypertension and Masked Nocturnal Hypertension in a Tertiary Hospital in the City of Buenos Aires

  2023cited by this paper
• Reclassification of Adolescent Ambulatory Prehypertension and Unclassified Blood Pressures by 2022 American Heart Association Pediatric Ambulatory Blood Pressure Monitoring Guidelines.

  2023cited by this paper
• The Novel Ceramide- and Phosphatidylcholine-Based Risk Score for the Prediction of New-Onset of Hypertension

  2023cited by this paper
• Isolated Nocturnal Hypertension in People Living with Human Immunodeficiency Virus (PWH): A Cross-Sectional Study.

  2023cited by this paper
• Albuminuria is associated with 24-hour and night-time diastolic blood pressure in urinary tract infection with renal scarring.

  2023cited by this paper
• Isolated Nocturnal Hypertension in Children

  2022cited by this paper
• Epidemiology of Hypertension among Patients on Peritoneal Dialysis Using Standardized Office and Ambulatory Blood Pressure Recordings

  2022cited by this paper
• Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial

  2022cited by this paper
• Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study)

  2022cited by this paper
• Masked nocturnal hypertension as a result of high prevalence of non-dippers among apparently well-controlled hypertensive patients with type 2 diabetes mellitus: data from a prospective study

  2022cited by this paper
• Predicting Isolated Nocturnal Hypertension Using Dawn and Dusk Home Blood Pressure Monitoring

  2022cited by this paper
• Isolated nocturnal hypertension in relation to host and environmental factors and clock genes

  2022cited by this paper
• [Isolated nocturnal hypertension in individuals with human immunodeficiency virus].

  2022cited by this paper
• Hypertensive Phenotypes and Pattern of Ambulatory Blood Pressure in Patients of Diabetes Mellitus of Kashmir Valley

  2022cited by this paper
• CERT2 ceramide- and phospholipid-based risk score and major adverse cardiovascular events: A systematic review and meta-analysis.

  2022cited by this paper
• 2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement.

  2021cited by this paper
• Oxygen desaturation index as alternative parameter in screening patients with severe obstructive sleep apnea

  2021cited by this paper
• Isolated nocturnal hypertension in pediatric kidney transplant recipients

  2021cited by this paper
• The Key Role of Ambulatory Blood Pressure Monitoring in the Detection of Masked Hypertension and Other Phenomena in Frail Geriatric Patients

  2021cited by this paper
• Prevalence and characteristics of isolated nocturnal hypertension in the general population

  2021cited by this paper
• Missing Verification of Source Data in Hypertension Research

  2021cited by this paper
• CIRCULATING CERAMIDE AS A POTENTIAL BIOMARKER FOR ISOLATED NOCTURNAL HYPERTENSION

  2021cited by this paper
• Different effects of morning and nocturnal hypertension on target organ damage in chronic kidney disease

  2021cited by this paper
• A commentary on the Spanish hypertension studies MAPEC and HYGIA

  2020cited by this paper
• Prevalence of isolated nocturnal hypertension according to 2018 European Society of Cardiology and European Society of Hypertension office blood pressure categories.

  2020cited by this paper
• Seasonal variation in blood pressure: Evidence, consensus and recommendations for clinical practice. Consensus statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability.

  2020cited by this paper
• Impact of bedtime dosing of antihypertensives compared to morning therapy: A meta-analysis of randomised controlled trials.

  2020cited by this paper
• Chronotherapy in hypertension: the devil is in the details.

  2020cited by this paper
• Isolated Nocturnal Hypertension: What Do We Know and What Can We Do?

  2020cited by this paper
• 2020 International Society of Hypertension Global Hypertension Practice Guidelines.

  2020cited by this paper
• Nocturnal blood pressure: the dark side of white-coat hypertension.

  2020cited by this paper
• Ambulatory Blood Pressure Monitoring in HIV-Infected Patients: Usefulness for Cardiovascular Risk Assessment

  2020cited by this paper
• Office and Ambulatory Arterial Hypertension in Highlanders

  2020cited by this paper
• Isolated nocturnal and isolated daytime hypertension associate with altered cardiovascular morphology and function in children with chronic kidney disease: findings from the Cardiovascular Comorbidity in Children with Chronic Kidney Disease study.

  2019cited by this paper
• Seasonal blood pressure variation assessed by different measurement methods: systematic review and meta-analysis.

  2019cited by this paper
• Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial.

  2019cited by this paper
• Dosing time matters

  2019cited by this paper
• Nighttime Blood Pressure Measured by Home Blood Pressure Monitoring as an Independent Predictor of Cardiovascular Events in General Practice

  2019cited by this paper
• Cardiovascular Events and Mortality in White Coat Hypertension

  2019cited by this paper
• Prevalencia de hipertensión enmascarada en niños con factores de riesgo para el desarrollo de hipertensión arterial

  2018cited by this paper
• Has the Sun Set on Nighttime Dosing in Uncomplicated Hypertension?

  2018cited by this paper
• Protocol for assessment of sleep quality and duration in the Treatment In Morning versus Evening (TIME) study: a randomised controlled trial using online patient-reported outcome measures

  2018cited by this paper
• Nocturnal Hypertension: New Technology and Evidence

  2018cited by this paper
• Nocturnal blood pressure patterns and cardiovascular outcomes in patients with masked hypertension

  2018cited by this paper
• Monitoreo ambulatorio de la presión arterial en pacientes diabéticos con o sin hipertensión arterial

  2018cited by this paper
• Ambulatory blood pressure monitoring in school children with a history of extreme prematurity.

  2018cited by this paper
• Hypertension in HIV-Infected Adults: Novel Pathophysiologic Mechanisms

  2018cited by this paper
• Sleep apnoea in patients with nocturnal hypertension - a multicenter study in the Czech Republic.

  2018cited by this paper
• Randomized Crossover Trial of the Impact of Morning or Evening Dosing of Antihypertensive Agents on 24-Hour Ambulatory Blood Pressure: The HARMONY Trial

  2018cited by this paper
• 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

  2018cited by this paper
• Is night-time hypertension worse than daytime hypertension? A study on cardiac damage in a general population: the PAMELA study

  2017cited by this paper
• Masked Isolated Nocturnal Hypertension in Children and Young Adults

  2017cited by this paper
• Nocturnal but not Diurnal Hypertension Is Associated to Insulin Resistance Markers in Subjects With Normal or Mildly Elevated Office Blood Pressure

  2017cited by this paper
• Non-Dipping and Cardiometabolic Profile: A Study on Normotensive Overweight Middle-Aged Men.

  2016cited by this paper
• Prognostic Effect of Isolated Nocturnal Hypertension in Chinese Patients With Nondialysis Chronic Kidney Disease

  2016cited by this paper
• Is Isolated Nocturnal Hypertension A Reproducible Phenotype?

  2016cited by this paper
• High Prevalence of Isolated Nocturnal Hypertension in Chinese Patients With Chronic Kidney Disease

  2015cited by this paper
• Sleep Blood Pressure Self‐Measured at Home as a Novel Determinant of Organ Damage: Japan Morning Surge Home Blood Pressure (J‐HOP) Study

  2015cited by this paper
• White-coat hypertension, as defined by ambulatory blood pressure monitoring, and subclinical cardiac organ damage: a meta-analysis

  2015cited by this paper
• Prehypertension, hypertension, and the risk of acute myocardial infarction in HIV-infected and -uninfected veterans.

  2014cited by this paper
• High prevalence of masked uncontrolled hypertension in people with treated hypertension.

  2014cited by this paper
• A Trial of 2 Strategies to Reduce Nocturnal Blood Pressure in Blacks With Chronic Kidney Disease

  2013cited by this paper
• Correlates of isolated nocturnal hypertension and target organ damage in a population-based cohort of African Americans: the Jackson Heart Study.

  2013cited by this paper
• Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome.

  2012cited by this paper
• Nighttime Home Blood Pressure and the Risk of Hypertensive Target Organ Damage

  2012cited by this paper
• Cardiovascular risk estimation in 2012: lessons learned and applicability to the HIV population.

  2012cited by this paper
• Nocturnal blood pressure in untreated essential hypertensives

  2011cited by this paper
• Evening versus morning dosing regimen drug therapy for hypertension.

  2011cited by this paper
• Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations

  2010cited by this paper
• INFLUENCE OF CIRCADIAN TIME OF HYPERTENSION TREATMENT ON CARDIOVASCULAR RISK: RESULTS OF THE MAPEC STUDY

  2010cited by this paper
• Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study

  2010cited by this paper
• Nocturia, Nocturnal Activity, and Nondipping

  2009cited by this paper
• Masked nocturnal hypertension—a novel marker of risk in type 2 diabetes

  2009cited by this paper
• Prevalence and Factors Associated With Circadian Blood Pressure Patterns in Hypertensive Patients

  2009cited by this paper
• Utility and feasibility of a new programmable home blood pressure monitoring device for the assessment of nighttime blood pressure

  2009cited by this paper
• Obstructive sleep apnea syndrome and hypertension: ambulatory blood pressure

  2009cited by this paper
• Daytime and Nighttime Blood Pressure as Predictors of Death and Cause-Specific Cardiovascular Events in Hypertension

  2008cited by this paper
• Nocturnal blood pressure versus nondipping pattern: what do they mean?

  2008cited by this paper
• Isolated nocturnal hypertension and arterial stiffness in a Chinese population

  2008cited by this paper
• Is Isolated Nocturnal Hypertension a Novel Clinical Entity?: Findings From a Chinese Population Study

  2007cited by this paper
• The International Database of Ambulatory blood pressure in relation to Cardiovascular Outcome (IDACO): protocol and research perspectives

  2007cited by this paper
• Ambulatory Blood Pressure and Cardiovascular Outcome in Relation to Perceived Sleep Deprivation

  2007cited by this paper
• Masked Nocturnal Hypertension and Target Organ Damage in Hypertensives with Well-Controlled Self-Measured Home Blood Pressure

  2007cited by this paper
• Ambulatory blood pressure and brain atrophy in the healthy elderly

  2002cited by this paper
• Alterations of Cardiac Structure in Patients With Isolated Office, Ambulatory, or Home Hypertension: Data From the General Population (Pressione Arteriose Monitorate E Loro Associazioni [PAMELA] Study)

  2001cited by this paper
• Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators.

  2000cited by this paper
• Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.

  2000cited by this paper
• Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension *

  1997cited by this paper
• Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.

  1997cited by this paper

• JHH Young Investigator Award 2025: Interview with the winner Julian Minetto

  2026cites this paper