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Biological effects of two nano-composite resins on human gingival fibroblast (an in vitro study)

Mai Gamal Mahmoud,Ali Shamaa,N. Bakr,Maha El Shahawy

Published 2025 in Journal of Oral Biology and Craniofacial Research

ABSTRACT

Objective To elucidate the genotoxic and cytotoxic effects of two different nano-composite resins on primary human gingival fibroblasts (HGFs). Methods The HGFs were isolated, characterized, and classified into 3 groups. The control group consisted of untreated HGFs, the Omnichroma extract treated HGFs (the OMN group), and the 3M Filtek Z350 xt extract treated HGFs (ESPE group). The cell viability, mode of cell death and expression of interleukin-1β (IL-1β) and interleukin-6 (IL-6) were investigated after 72 h and 24 h of resin extracts' pre-incubation with HGF. Results The isolated HGFs were characterized. The HGF viability was significantly higher in the OMN groups than ESPE groups at most of the concentrations. Total cell death was higher in the ESPE groups and at the OMN group at 72 h in comparison to the control and was higher in the ESPE groups compared to OMN groups. Furthermore, the IL-1β and IL-6 levels in the OMN group at 72 h and in the ESPE groups were higher than the control one. Conclusion The cytotoxic and genotoxic effect of ESPE on HGF is more significant than the OMN.

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