Tamper-resistant drugs cannot solve the opioid crisis

Tamper-resistant formulations, designed to make drugs harder to crush, snort or inject, are being promoted in Canada and the United States as a strategy to prevent opioid-related harms such as overdose and addiction. In a research article published in CMAJ Open , Gomes and colleagues[1][1] examined

• Publication year

  2015

• Venue

  Canadian Medical Association Journal

• Publication date

  2015-06-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.1503/cmaj.150329PMID 26124228PMCID PMC4500686
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States: Lessons Learned From OxyContin.

  2015cited by this paper
• The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction.

  2015cited by this paper
• Drug-poisoning deaths involving heroin: United States, 2000-2013.

  2015cited by this paper
• Retrospective analysis of trends in dispensing long-acting non-tamper-resistant oxycodone near the Canada-United States border.

  2015cited by this paper
• Reductions in reported deaths following the introduction of extended-release oxycodone (OxyContin) with an abuse-deterrent formulation†

  2014cited by this paper
• Characteristics of Opioid-Users Whose Death Was Related to Opioid-Toxicity: A Population-Based Study in Ontario, Canada

  2013cited by this paper
• Tampering with Prescription Opioids: Nature and Extent of the Problem, Health Consequences, and Solutions

  2011cited by this paper
• Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone

  2009cited by this paper
• Co‐morbid pain and psychopathology in males and females admitted to treatment for opioid analgesic abuse☆

  2008cited by this paper

• Reframing the Overdose Crisis: Stigma, Industry Influence, and the Politics of Abuse-Deterrent Opioids

  2025cites this paper
• Profit and Prudence: Navigating Psychedelic Commercialization Through Lessons from the Prescription Opioid Crisis.

  2023cites this paper
• The opioid industry document archive: New directions in research on corporate political strategy.

  2023cites this paper
• Identification of factors influencing tampering of codeine-containing medicines in England: a qualitative study

  2020cites this paper
• The opioid crisis: a contextual, social-ecological framework

  2020cites this paper
• A retrospective cohort study evaluating correlates of deep tissue infections among patients enrolled in opioid agonist treatment using administrative data in Ontario, Canada

  2020cites this paper
• Review of Coroner Inquest Recommendations into Opioid Prescribing Practices in Ontario: Ongoing Health Policy Gaps

  2019cites this paper
• Silk Fibroin as a Novel Alcohol-Resistant Excipient for Sustained-Release Tablet Formulation

  2019cites this paper
• Causal inference for evaluating prescription opioid abuse using trend‐in‐trend design

  2019cites this paper
• The Opioid Crisis: A Contextual Framework and Call for Systems Science Research

  2019influential citation
• Creating Clinical Cohorts: Challenges Encountered in Two Canadian Provinces

  2019cites this paper
• The opioid epidemic in the United States—Overview, origins, and potential solutions

  2018cites this paper
• Person-level changes in oxycodone use after the introduction of a tamper-resistant formulation in Australia

  2018cites this paper
• Characteristics of opioid-maintained clients smoking fentanyl patches: The importance of confirmatory drug analysis illustrated by a case series and mini-review.

  2018cites this paper
• Embracing the wild profusion: A Foucauldian analysis of the impact of healthcare standardization on nursing knowledge and practice

  2018cites this paper
• Pain Town, an Agent-Based Model of Opioid Use Trajectories in a Small Community

  2018cites this paper
• Prescription Medication Misuse

  2018cites this paper
• Overdose Education and Naloxone Distribution Programmes and the Ethics of Task Shifting

  2018cites this paper
• Ethics at the Intersection of Chronic Pain and Substance Use

  2018cites this paper
• The opioid crisis: past, present and future policy climate in Ontario, Canada

  2017cites this paper
• Responsible, Safe, and Effective Prescription of Opioids for Chronic Non-Cancer Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines.

  2017cites this paper
• Opioids, naloxone, and beyond: The intersection of medication safety, public health, and pharmacy.

  2017cites this paper
• The Opioid Epidemic: Postoperative Pain Management Strategies in Orthopaedics

  2017cites this paper
• The Perils of Pain: Applying Primary Prevention to Combat Canada's Opioid Crisis

  2017influential citation
• ‘Delisting’ OxyContin® to reduce prescription opioid‐related harms in Ontario (Canada)—gauging effects 5 years later

  2017cites this paper
• How Resistant to Tampering are Codeine Containing Analgesics on the Market? Assessing the Potential for Opioid Extraction

  2016cites this paper
• Sustained reduction of diversion and abuse after introduction of an abuse deterrent formulation of extended release oxycodone.

  2016cites this paper
• The Lancet Commissions

  2016cites this paper
• Current State of Opioid Therapy and Abuse

  2016cites this paper
• Misuse of 'over-the-counter' codeine analgesics: does formulation play a role?

  2016cites this paper
• Opioid Use and Overdose: What We've Learned in Ontario.

  2016cites this paper
• Effective Canadian policy to reduce harms from prescription opioids: learning from past failures

  2016cites this paper
• Public health and international drug policy.

  2016cites this paper
• Opioid misuse: containing harms.

  2016cites this paper
• Tampering of opioid analgesics: a serious challenge for public health?

  2016cites this paper
• Addressing the Opioid Epidemic.

  2015cites this paper