Integrative single-cell and spatial transcriptome analysis reveals the functions of TREM2high macrophages and infarct border dynamics post-myocardial infarction

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Molecular and Cellular Biochemistry

• Publication date

  2025-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11010-025-05317-9PMID 40750734
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasets

  2024cited by this paper
• Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability—Brief Report

  2023cited by this paper
• Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling

  2023cited by this paper
• Immune cells drive new immunomodulatory therapies for myocardial infarction: From basic to clinical translation

  2023cited by this paper
• The role of cardiac pericytes in health and disease: therapeutic targets for myocardial infarction

  2023cited by this paper
• TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis

  2023cited by this paper
• Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues

  2023cited by this paper
• Pathways linking aging and atheroprotection in Mif‐deficient atherosclerotic mice

  2023cited by this paper
• The Protective Role of TREM2 in the Heterogenous Population of Macrophages during Post-Myocardial Infarction Inflammation

  2023cited by this paper
• Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction

  2022cited by this paper
• Diagnosis and Treatment of Acute Coronary Syndromes: A Review.

  2022cited by this paper
• OUP accepted manuscript

  2022cited by this paper
• Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

  2022cited by this paper
• Cell2location maps fine-grained cell types in spatial transcriptomics

  2022cited by this paper
• Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis

  2022cited by this paper
• Single-cell and spatial transcriptomics of the infarcted heart define the dynamic onset of the border zone in response to mechanical destabilization

  2022cited by this paper
• Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts

  2022cited by this paper
• NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data

  2021cited by this paper
• Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.

  2021cited by this paper
• Triggering receptor expressed on myeloid cells-2 promotes survival of cardiomyocytes after myocardial ischemic injury through PI3K/AKT pathway.

  2021cited by this paper
• Doublet identification in single-cell sequencing data using scDblFinder

  2021cited by this paper
• Differential abundance testing on single-cell data using K-nearest neighbour graphs

  2021cited by this paper
• Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds

  2021cited by this paper
• The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis.

  2021cited by this paper
• Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes

  2020cited by this paper
• Spatial multi-omic map of human myocardial infarction

  2020cited by this paper
• LncRNA SNHG14 promotes OGD/R-induced neuron injury by inducing excessive mitophagy via miR-182-5p/BINP3 axis in HT22 mouse hippocampal neuronal cells

  2020influential reference
• The study of border zone formation in ischemic heart using electro‐chemical coupled computational model

  2020cited by this paper
• The Broad Spectrum of LMNA Cardiac Diseases: From Molecular Mechanisms to Clinical Phenotype

  2020cited by this paper
• CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

  2020cited by this paper
• NicheNet: modeling intercellular communication by linking ligands to target genes

  2019cited by this paper
• Chemokines as Therapeutic Targets in Cardiovascular Disease: The Road Behind, The Road Ahead

  2019cited by this paper
• Fast, sensitive, and accurate integration of single cell data with Harmony

  2019cited by this paper
• Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

  2019cited by this paper
• Integrating single-cell transcriptomic data across different conditions, technologies, and species

  2018cited by this paper
• SCANPY: large-scale single-cell gene expression data analysis

  2018cited by this paper
• Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

  2018cited by this paper
• Post-Myocardial Infarction Heart Failure.

  2018cited by this paper
• Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis

  2018cited by this paper
• Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

  2017cited by this paper
• Fcγ Receptor Heterogeneity in Leukocyte Functional Responses

  2017cited by this paper
• SCENIC: Single-cell regulatory network inference and clustering

  2017cited by this paper
• Massively parallel digital transcriptional profiling of single cells

  2016influential reference
• Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

  2016cited by this paper
• Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism

  2016cited by this paper
• TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

  2016cited by this paper
• The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis.

  2016cited by this paper
• Macrophages in Tissue Repair, Regeneration, and Fibrosis.

  2016cited by this paper
• limma powers differential expression analyses for RNA-sequencing and microarray studies

  2015cited by this paper
• Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

  2014cited by this paper
• Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions

  2014cited by this paper
• Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

  2014cited by this paper
• The Immune System and the Remodeling Infarcted Heart: Cell Biological Insights and Therapeutic Opportunities

  2014cited by this paper
• Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings.

  2014cited by this paper
• Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

  2014cited by this paper
• The hyperferritinemic syndromes and CD163: a marker of macrophage activation.

  2014cited by this paper
• Anti-inflammatory strategies for ventricular remodeling following ST-segment elevation acute myocardial infarction.

  2014cited by this paper
• GSVA: gene set variation analysis for microarray and RNA-Seq data

  2013cited by this paper
• S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease

  2013cited by this paper
• Post-infarction inflammation and left ventricular remodeling: a double-edged sword.

  2013cited by this paper
• Hypoxia Enhances the Proliferative Response of Macrophages to CSF-1 and Their Pro-Survival Response to TNF

  2012cited by this paper
• IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuR

  2009cited by this paper
• The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

  2007cited by this paper
• Resolution of inflammation: the beginning programs the end

  2005cited by this paper
• CCL2/Monocyte Chemoattractant Protein-1 Regulates Inflammatory Responses Critical to Healing Myocardial Infarcts

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Border zone geometry increases wall stress after myocardial infarction: contrast echocardiographic assessment.

  2003cited by this paper
• A blast from the past: clearance of apoptotic cells regulates immune responses

  2002cited by this paper
• Extension of borderzone myocardium in postinfarction dilated cardiomyopathy.

  2002cited by this paper
• Adhesion molecules and inflammatory injury

  1994cited by this paper
• Pathophysiological mechanisms of ventricular tachyarrhythmias.

  1989cited by this paper
• Ultrastructural changes in the ischemic zone bordering experimental infarcts in rat left ventricles.

  1977cited by this paper

• Silent Myocardial Infarction Revisited: Immuno-metabolic Mechanisms, Multimodal Biomarkers, and Translational Diagnostics.

  2026cites this paper