Effects of Dietary Adjustment and Fish Oil on Lipid Metabolism, Inflammation, and Serum LPS in Non-Alcoholic Fatty Liver Disease.

We compared the therapeutic effects of dietary adjustment and fish oil in rats with experimental non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The NAFLD rats were either maintained on high-fat diet, or transferred from high-fat diet to normal diet, or received a diet with lard replaced with fish oil. Control rats received normal diet throughout the experiment. The liver coefficient, blood lipids, activities of transaminases, and the severity of hepatic steatosis in NAFLD rats were improved by both dietary adjustment and fish oil (p < 0.05). Dietary adjustment led to a significant decrease in the levels of inflammatory factors in the liver of NAFLD rats (p < 0.05); in rats receiving fish oil, these parameters also tended to decrease. A large number of inflammatory cells were found in the colonic mucosa of rats fed with high-fat diet and the serum level of LPS in these rats was higher than in the control. Neither dietary adjustment, nor fish oil consumption reduced the serum level of LPS in NAFLD rats. Thus, dietary adjustment and fish oil administration improved the levels of blood lipids and liver inflammation in NAFLD rats. The beneficial effect of dietary adjustment on the level of liver inflammation in NAFLD was more pronounced.

• Publication year

  2026

• Venue

  Bulletin of experimental biology and medicine

• Publication date

  2026-02-09

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.47056/0365-9615-2025-180-7-51-59PMID 41661428
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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