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Minimally Invasive Total Versus Partial Thymectomy for Early-Stage Thymoma

Alexander Pohlman,Bilal Odeh,Irene Helenowski,Julia M Coughlin,W. Raad,James Lubawski,Z. Abdelsattar

Published 2025 in Cancers

ABSTRACT

Simple Summary Total thymectomy is the current standard for the treatment of early-stage thymoma. However, recent studies have raised partial thymectomy as an option and brought attention to the thymus’s potential role in protection against autoimmune disease, development of extra-thymic malignancy and overall mortality. Therefore, it’s unclear if an organ-sparing approach is an equivalent alternative. In this context, we compare partial versus total thymectomy for early-stage thymoma using a national database. We demonstrate that partial- and total-thymectomy have similar short- and long-term outcomes. These results may help better inform patients of their surgical options within shared decision making discussions with their surgeon.

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