Trifluoroethyl Methanesulfonate (Methylsulfonyl) (TFMSMS) on DPPC Membrane: Study of an Interaction of a Bioactive Compound

The interactions of trifluoroethyl methanesulfonate (methylsulfonyl) (TFMSMS), a lipophilic bioactive derivative of Clomesone, with dipalmitoylphosphatidylcholine (DPPC) were investigated. Thermodynamic changes caused by TFMSMS in DPPC lipid bilayers were monitored using differential scanning calorimetry (DSC), FTIR, and Raman spectroscopy. TFMSMS influenced the thermotropic properties of DPPC membranes, abolishing the pretransition, broadening the phase‐transition profile, and decreasing the Tm with increasing concentrations. Raman spectroscopy revealed TFMSMS interactions with alkyl chains, altering the order–disorder ratio. A blue shift in the peak at 3036 cm−1 and the appearance of a new band at 3026 cm−1 indicated a strong interaction between the choline head group and TFMSMS. FTIR results supported these findings, showing changes in the phosphate and carbonyl groups. Our research highlights the active role of lipids in cellular functions and the potential of TFMSMS in inhibiting pathogenic bacterial growth and biofilm formation.

• Publication year

  2025

• Venue

  Journal of Raman Spectroscopy

• Publication date

  2025-07-30

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1002/jrs.70021
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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