SCIENCE@home

Exercise Ameliorates Dopaminergic Neurodegeneration in Parkinson’s Disease Mice by Suppressing Microglia-Regulated Neuroinflammation Through Irisin/AMPK/Sirt1 Pathway

Bin Wang,Nan Li,Yuanxin Wang,Xin Tian,Junjie Lin,Xin Zhang,Haocheng Xu,Yu Sun,Renqing Zhao

Published 2025 in Biology

ABSTRACT

Simple Summary This study demonstrates that 10 weeks of exercise improves motor function and protects dopamine-producing neurons in a Parkinson’s disease (PD) mouse model. Exercise reduces brain inflammation by shifting microglia (immune cells in the brain) from an inflammatory state to a protective state. These benefits are linked to increased levels of irisin, a muscle-derived hormone, which activates the AMPK/Sirt1 pathway—a key regulator of energy metabolism and inflammation. Blocking irisin’s receptor reversed these positive effects, confirming its role in exercise-induced neuroprotection. These findings suggest that exercise, through irisin signaling, may help slow PD progression by reducing inflammation and neuronal damage.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-80 of 80 references · Page 1 of 1

CITED BY