Role of circadian rhythm disruption and dietary polyphenols in the prognosis of neoadjuvant therapy for locally advanced colorectal cancer.

OBJECTIVE To explore the influence of circadian rhythm disruption and dietary polyphenols on the prognosis of neoadjuvant therapy in patients with locally advanced colorectal cancer (CRC). METHODS A retrospective case-control study was conducted involving 262 patients with locally advanced CRC who received neoadjuvant therapy. Patients were categorized into good prognosis (n = 121) and poor prognosis (n = 141) groups based on Tumor Regression Grading. Data collected included demographic characteristics, work schedules, dietary intake, blood biomarkers, circadian rhythm assessments, and sleep quality metrics. Statistical analyses included chi-square tests, Pearson and Spearman correlations, and Receiver Operating Characteristic curve analysis to identify significant prognostic indicators. RESULTS Favorable prognostic factors included younger age, better Eastern Cooperative Oncology Group performance status, lower Tumor-Node-Metastasis stage, absence of night shift work, regular work schedules, and greater exposure to natural light. Higher dietary polyphenol intake - primarily from fruits, vegetables, and plant-based foods - was significantly associated with improved treatment response. In contrast, disrupted cortisol rhythms and poor sleep quality predicted worse outcomes. Total polyphenol intake demonstrated strong predictive power (Area Under the Curve [AUC] = 0.847), as did cortisol rhythm disruption (AUC = 0.810). CONCLUSION Stability of circadian rhythms and higher dietary polyphenol intake were associated with improved responses to neoadjuvant therapy in patients with locally advanced CRC.

• Publication year

  2025

• Venue

  American Journal of Cancer Research

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.62347/dizo2176PMID 40814380PMCID PMC12344153
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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