Insulin receptors of cultured human lymphocytes (IM-9). Lack of receptor-mediated degradation.

No abstract is available for this paper.

• Publication year

  1980

• Venue

  Journal of Biological Chemistry

• Publication date

  1980-08-10

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 6993488
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

  1980cited by this paper
• Mode of uptake and degradation of 125I-labelled insulin by isolated hepatocytes and H4 hepatoma cells.

  1979cited by this paper
• Biological potency and binding affinity of monoiodoinsulin with iodine in tyrosine A14 or tyrosine A19.

  1979cited by this paper
• Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits.

  1979cited by this paper
• Kinetic parameters of transport of 3-O-methylglucose and glucose in adipocytes.

  1979cited by this paper
• Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

  1979cited by this paper
• 125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

  1978cited by this paper
• Binding of 125I-labeled glucagon and glucagon-stimulated accumulation of adenosine 3':5'-monophosphate in isolated intact rat hepatocytes. Evidence for receptor heterogeneity.

  1978cited by this paper
• Intracellular translocation of iodine-125-labeled insulin: direct demonstration in isolated hepatocytes.

  1978cited by this paper
• Insulin receptors in isolated rat hepatocytes. Reassessment of binding properties and observations of the inactivation of insulin at 37 degrees C.

  1978cited by this paper
• Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

  1978cited by this paper
• Binding and receptor-mediated degradation of insulin in adipocytes.

  1978cited by this paper
• Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model.

  1977cited by this paper
• Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

  1977cited by this paper
• THE MECHANISM OF ACTION OF POLYPEPTIDE HORMONES WITH SPECIAL REFERENCE TO INSULIN'S ACTION ON GLUCOSE TRANSPORT

  1977cited by this paper
• Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

  1976cited by this paper
• Receptor-binding region of insulin

  1976cited by this paper
• Binding and degradation of 125I-insulin by rat hepatocytes.

  1975cited by this paper
• A rapid technique for separation of thymocytes from suspensions by centrifugation through silicone oil.

  1974cited by this paper
• Characteristics of the human lymphocyte insulin receptor.

  1973cited by this paper
• Binding and degradation of 125I-labelled insulin by isolated rat fat cells.

  1973cited by this paper
• Characterization of a rat liver protease with specificity for insulin.

  1972cited by this paper
• Insulin--receptor interactions in adipose tissue cells: direct measurement and properties.

  1971cited by this paper
• DEIODINATION OF THE IODINATED AMINO ACIDS *

  1960cited by this paper

• High affinity binding sites for proinsulin in human IM-9 lymphoblasts

  1996cites this paper
• Structural and functional heterogeneity of insulin receptors.

  1995cites this paper
• Insulin receptor characterization and function in bovine aorta endothelial cells: Insulin degradation by a plasma membrane, protease‐resistant insulin receptor

  1993cites this paper
• Dynamics of atrial natriuretic factor-guanylate cyclase receptors and receptor-ligand complexes in cultured glomerular mesangial and renomedullary interstitial cells.

  1992cites this paper
• Diacylglycerols Modulate Insulin Action in Rat Adipocytes

  1991cites this paper
• Urokinase receptors in human monocytes.

  1990cites this paper
• Relationships between cell surface insulin binding and endocytosis in adipocytes.

  1988cites this paper
• Receptor-mediated endocytosis and degradation of insulin.

  1988cites this paper
• Characteristics of insulin receptors in a human lymphoblastoid cell line (Raji).

  1988cites this paper
• Insulin and insulinlike growth factor receptors regulating neurite formation in cultured human neuroblastoma cells

  1988cites this paper
• Receptor-mediated degradation of insulin in isolated rat adipocytes. Formation of a degradation product slightly smaller than insulin.

  1987cites this paper
• The reversible receptor binding of insulin in isolated rat adipocytes measured at 37 degrees C. The binding is not rate limiting for cellular uptake.

  1986cites this paper
• Metabolism of a mutant insulin by a receptor-mediated process and an insulin degrading enzyme.

  1986cites this paper
• Insulin binding to differentiating muscle cell line L6.

  1986cites this paper
• Protein kinase activity of the insulin receptor.

  1986cites this paper
• Equilibrium binding of insulin to rat white fat cells at 15 degrees C.

  1986cites this paper
• Cell Type-Specific Variability of Bacitracin's Effects on Insulin Binding and Intracellular Accumulation

  1986cites this paper
• Kinetics of insulin binding to rat white fat cells at 15 degrees C.

  1986cites this paper
• A kinetic analysis of hexose transport in cultured human lymphocytes (IM-9).

  1985cites this paper
• Studies on Insulin Receptors: Implications for Insulin Action

  1985cites this paper
• In vitro recovery of insulin binding after downregulation in cultured normal human monocytes.

  1985cites this paper
• Neurite formation modulated by nerve growth factor, insulin, and tumor promoter receptors.

  1985cites this paper
• Increased inhibitory potency of free fatty acid-poor albumin on the released and activity of insulin-degrading enzymes from isolated rat adipocytes and hepatocytes.

  1985cites this paper
• Characterization of an insulin degrading enzyme from cultured human lymphocytes.

  1985cites this paper
• Processing of cell-bound insulin by capillary and macrovascular endothelial cells in culture.

  1985cites this paper
• Receptor-mediated degradation of human growth hormone in rat adipocytes and cultured human lymphocytes (IM-9).

  1985cites this paper
• [Evidence for the internalization and degradation of insulin in cultured Bri-7K human lymphocytes].

  1985cites this paper
• Receptor-mediated degradation and internalization of insulin in the adenocarcinoma cell line HT-29 from human colon.

  1985cites this paper
• Insulin binding and degradation in short time incubation at 37 C.

  1984cites this paper
• Equilibrium model for insulin-induced receptor down-regulation. Regulation of insulin receptors in differentiated BC3H-1 myocytes.

  1984cites this paper
• Insulin receptors in rat brain cortex. Kinetic evidence for a receptor subtype in the central nervous system.

  1984cites this paper
• Liver cells binding with high insulin doses at 37 C.

  1984cites this paper
• Subcellular sites of insulin hydrolysis in renal proximal tubules.

  1984cites this paper
• [Insulin degrading system on isolated rat hepatocytes; enzymatic and immunologic characteristics of insulin-degrading activities].

  1984cites this paper
• Insulin receptors: binding kinetics and structure-function relationship of insulin.

  1984cites this paper
• Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells.

  1984cites this paper
• Internalization and acidification of insulin by activated human lymphocytes

  1984cites this paper
• Internalization of insulin and its receptor in the isolated rat adipose cell. Time-course and insulin concentration dependency.

  1984cites this paper
• Receptor-binding kinetics of A-14 and A-19 125I-labelled insulin.

  1984cites this paper
• Insulin binding on MOLT 4 cells: effect of a sulfonylurea.

  1984cites this paper
• インスリン受容体の親和性変化 温度変化時のKinetic Study

  1984cites this paper
• Studies on the inhibitory effect of bacitracin on 125I-labelled insulin internalization in the rat hepatocyte.

  1983cites this paper
• Insulin receptors.

  1983cites this paper
• Insulin receptors of human term placental cells and choriocarcinoma (JEG-3) cells: characteristics and regulation.

  1983cites this paper
• Evidence of the lack of receptor-mediated insulin degradation in human cultured lymphocytes (RPMI-1788 line).

  1983cites this paper
• The mechanism of receptor-mediated degradation of insulin in isolated rat adipocytes: indirect evidence for a non-lysosomal pathway.

  1983cites this paper
• Degradation of the four monoiodoinsulin isomers by the insulin protease of rat liver.

  1983cites this paper
• Binding and degradation of 125I-labeled insulin by a clonal line of rat pituitary tumor cells.

  1983cites this paper
• Insulin binding and metabolism by primary cultures of rat hepatocytes: evidence for intracellular location of the low affinity binding sites.

  1982cites this paper
• Direct linkage of 125I-EGF to cell surface receptors. A useful artifact of chloramine-T treatment.

  1982cites this paper
• Inhibition of insulin receptor binding by phorbol esters.

  1982cites this paper
• Structure of the insulin receptor of the cultured human lymphoblastoid cell IM-9. Evidence suggesting that two subunits are required for insulin binding.

  1982cites this paper
• Development of insulin responsiveness of the glucose transporter and the (Na+,K+)-adenosine triphosphatase during in vitro adipocyte differentiation.

  1982cites this paper
• Insulin binding in cultured Chinese hamster kidney epithelial cells: The effect of serum in the medium

  1982cites this paper
• Receptor-mediated insulin degradation and insulin-stimulated glycogenesis in cultured foetal hepatocytes.

  1982cites this paper
• 125I-labelled insulin degradation by isolated rat hepatocytes: The roles of glutathione-insulin transhydrogenase and insulin-specific protease

  1982cites this paper
• Receptors for Regulatory Peptides in Epithelial Gut Cancer

  1982cites this paper
• Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

  1982cites this paper
• Binding and degradation of 125l-insulin in human erythrocytes. Comparative studies with hemolysate and membranes.

  1982cites this paper
• Photoaffinity Labeling of Insulin Receptors in Viable Cultured Human Lymphocytes: Demonstration of Receptor Shedding and Degradation

  1982cites this paper
• Internalization and intracellular processing of insulin and insulin receptors in adipocytes.

  1982cites this paper
• The fate of insulin in cardiac muscle. Studies on isolated muscle cells from adult rat heart.

  1982cites this paper
• The cellular distribution of A14-(125I)monoiodoinsulin after incubation with cultured human lymphocytes (IM-0). A quantitative electronmicroscope autoradiographic study.

  1982cites this paper
• [The structure and function of insulin].

  1982cites this paper
• Identification of insulin-degrading enzyme on the surface of cultured human lymphocytes, rat hepatoma cells, and primary cultures of rat hepatocytes.

  1982cites this paper
• Down-regulation of insulin receptors in primary cultures of R3230 AC rat mammary adenocarcinoma cells.

  1982cites this paper
• Binding and degradation of 125I-insulin by renal glomeruli and tubules isolated from rats

  1982cites this paper
• Inhibition by bacitracin of rat adipocyte plasma membrane degradation of 125I-insulin is associated with an increase in plasma membrane bound insulin and a potentiation of glucose oxidation by adipocytes.

  1982cites this paper
• Insulin receptors convert to a higher affinity state subsequent to hormone binding. A two-state model for the insulin receptor.

  1982cites this paper
• Internalization of 125I-Insulin by IM-9 Cultured Human Lymphocytes: A Comparison Between A14-Monoiodo-Pork and Biosynthetic Human Insulin

  1981cites this paper
• Characterization of Insulin-induced Receptor Loss and Evidence for Internalization of the Insulin Receptor

  1981cites this paper
• The binding of 125I-insulin to specific receptors in IM-9 human lymphocytes. Detection of radioactivity covalently linked to receptors.

  1981cites this paper
• Tyrosine A14 [125I]monoiodoinsulin: Preparation, Biologic Properties, and Long-term Stability

  1981cites this paper
• Bacitracin: an inhibitor of the insulin degrading activity of glutathione-insulin transhydrogenase.

  1981cites this paper
• Vasoactive intestinal polypeptide modulation of lymphocyte adenylate cyclase.

  1981cites this paper
• Characterization of detergent-solubilized membrane proteins. Hydrodynamic and sedimentation equilibrium properties of the insulin receptor of the cultured human lymphoblastoid cell.

  1981cites this paper
• Insulin metabolism and degradation.

  1981cites this paper
• Negative cooperativity at the insulin receptor

  1981cites this paper
• Chloroquine stimulation of insulin binding to IM-9 lymphocytes: evidence for action at a nonlysosomal site.

  1981cites this paper
• Effect of pH on binding kinetics and biological effect of insulin in rat adipocytes.

  1981cites this paper
• Potency of Biosynthetic Human Insulin Determined In Vitro

  1981cites this paper
• Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors.

  1981cites this paper
• Insulin receptor: structure and function.

  1981cites this paper
• Insulin receptors on human lymphoid lines of B-cell origin

  1981cites this paper
• Role of insulin receptors in insulin resistance.

  1980cites this paper