The Fanconi Anemia Pathway Inhibits mTOR Signaling and Prevents Accelerated Translation in Head and Neck Cancer Cells

Simple Summary The Fanconi anemia (FA) pathway is essential for DNA repair and maintenance of genome integrity. Individuals born without a functional FA pathway are at high risk of developing head and neck cancer early in life, often with poor prognosis. We sought to define whether a nonfunctional FA pathway affects cellular metabolism and related signal transduction. FA loss stimulated amino acid accumulation, translation, and protein production via mTOR signaling, which is reported to promote cancer development and progression. Pharmacological mTOR inhibition using rapamycin suppressed these pro-cancer phenotypes, suggesting that targeting protein synthesis may offer a therapeutic avenue for the management of FA− associated cancers.

• Publication year

  2025

• Venue

  Cancers

• Publication date

  2025-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/cancers17152583PMID 40805278PMCID 12346401
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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