Altered striatal functional gradients in obsessive-compulsive disorder.

BACKGROUND Obsessive-compulsive disorder (OCD) is associated with functional alterations in how the striatum interacts with the rest of the brain. However, the characterization of these changes in OCD is incomplete. Mapping functional striatal gradients provides a new opportunity to fill this knowledge gap. These gradients provide a spatial representation of continuous changes in whole-brain connectivity within striatal regions. Thus, OCD-related differences in striatal gradients imply changes in the functional organisation of striatal connections. METHODS We calculated spatial striatal gradients linked to whole brain activity in 52 people with OCD and 45 controls. Gradients were computed with individuals at rest and when they underwent a threat-safety reversal task. Using a longitudinal dataset of 47 people with OCD, we investigated possible associations between changes in striatal gradient topology and fluctuations in symptom severity. RESULTS Results showed group differences in the main gradient topology at rest, specifically in striatal regions overlapping with the putamen and caudate. Individuals showing a reduction in symptoms over time tended to change their gradient topology in favour of the control participants' average topology. Finally, gradients linked to the appraisal of safety-reversal, but not threat-reversal, showed a group difference in a region separating the right nucleus accumbens and the putamen. CONCLUSIONS This study advances knowledge of striatal connectivity profiles in OCD, supporting a core role of distinct changes in striatal topology in the expression of symptoms. Collectively, these results encourage studies assessing neural mechanisms driving the dynamic reorganisation of striatal topology and the development of therapies leveraging striato-cortical plasticity.

• Publication year

  2025

• Venue

  Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

• Publication date

  2025-07-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.bpsc.2025.07.006PMID 40716670
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors

  2024cited by this paper
• Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder

  2024cited by this paper
• Data-driven and equation-free methods for neurological disorders: analysis and control of the striatum network

  2024cited by this paper
• Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior

  2024cited by this paper
• Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy

  2023cited by this paper
• Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal stimulation sites.

  2023cited by this paper
• Revisiting deficits in threat and safety appraisal in obsessive‐compulsive disorder

  2023cited by this paper
• Effects of transcranial magnetic stimulation of the rostromedial prefrontal cortex in obsessive–compulsive disorder: a randomized clinical trial

  2023cited by this paper
• Functional re-organization of hippocampal-cortical gradients during naturalistic memory processes

  2023cited by this paper
• Mechanisms of imbalanced frontostriatal functional connectivity in obsessive-compulsive disorder.

  2022cited by this paper
• Operational Definitions of Treatment Response and Remission in Obsessive-Compulsive Disorder Capture Meaningful Improvements in Everyday Life

  2022cited by this paper
• Striatal topographical organization: Bridging the gap between molecules, connectivity and behavior

  2021cited by this paper
• Mapping dopaminergic projections in the human brain with resting-state fMRI

  2021cited by this paper
• Toward a neurocircuit-based taxonomy to guide treatment of obsessive–compulsive disorder

  2021cited by this paper
• Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.

  2021cited by this paper
• A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

  2020cited by this paper
• Core and Matrix Thalamic Sub-Populations Relate to Spatio-Temporal Cortical Connectivity Gradients

  2020cited by this paper
• Topographic organization of the human subcortex unveiled with functional connectivity gradients

  2020cited by this paper
• Functional Connectivity of the Striatum as a Neural Correlate of Symptom Severity in Patient with Obsessive-Compulsive Disorder

  2020cited by this paper
• TOWARD A CONNECTIVITY GRADIENT-BASED FRAMEWORK FOR REPRODUCIBLE BIOMARKER DISCOVERY

  2020cited by this paper
• BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets

  2019cited by this paper
• Human cognition involves the dynamic integration of neural activity and neuromodulatory systems

  2019cited by this paper
• Obsessive-Compulsive Disorder: Puzzles and Prospects

  2019cited by this paper
• Microstructural and functional gradients are increasingly dissociated in transmodal cortices

  2019cited by this paper
• FMRIPrep: a robust preprocessing pipeline for functional MRI

  2018cited by this paper
• Precision Functional Mapping of Individual Human Brains.

  2017cited by this paper
• Neural basis of impaired safety signaling in Obsessive Compulsive Disorder

  2017cited by this paper
• Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder: Evidence From Resting-State Functional Connectivity

  2017cited by this paper
• Functional corticostriatal connection topographies predict goal directed behaviour in humans

  2017cited by this paper
• Principles of Synaptic Organization of GABAergic Interneurons in the Striatum.

  2016cited by this paper
• Situating the default-mode network along a principal gradient of macroscale cortical organization

  2016cited by this paper
• Connectopic mapping with resting‐state fMRI

  2016cited by this paper
• Corticostriatal circuitry

  2016cited by this paper
• Zen and the Art of Multiple Comparisons

  2015cited by this paper
• Machine learning for neuroimaging with scikit-learn

  2014cited by this paper
• Striatal circuits, habits, and implications for obsessive-compulsive disorder.

  2014cited by this paper
• Intrinsic and task-evoked network architectures of the human brain.

  2014cited by this paper
• Deficits in conditioned fear extinction in obsessive-compulsive disorder and neurobiological changes in the fear circuit.

  2013cited by this paper
• Morphologic and Functional Connectivity Alterations of Corticostriatal and Default Mode Network in Treatment-Naïve Patients with Obsessive-Compulsive Disorder

  2013cited by this paper
• Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder

  2013cited by this paper
• Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

  2013cited by this paper
• Genome-wide association study of obsessive-compulsive disorder

  2013cited by this paper
• Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

  2013cited by this paper
• Tools of the trade: psychophysiological interactions and functional connectivity.

  2012cited by this paper
• A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches

  2012cited by this paper
• Disruption in the Balance Between Goal-Directed Behavior and Habit Learning in Obsessive-Compulsive Disorder

  2011cited by this paper
• The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication

  2010cited by this paper
• Altered corticostriatal functional connectivity in obsessive-compulsive disorder.

  2009cited by this paper
• Cortical and Subcortical Contributions to Stop Signal Response Inhibition: Role of the Subthalamic Nucleus

  2006cited by this paper
• Frontal-striatal dysfunction during planning in obsessive-compulsive disorder.

  2005cited by this paper
• Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum

  2000cited by this paper
• Obsessive–compulsive disorder

  2000cited by this paper
• Psychophysiological and modulatory interactions in neuroimaging.

  1997cited by this paper
• Functional architecture of basal ganglia circuits: neural substrates of parallel processing.

  1990cited by this paper

• No citing papers are available for this paper.