WNT7A.

WNT7A regulates numerous developmental processes. It can activate canonical and non-canonical signaling depending on context. It is expressed in the developing central nervous system, limb buds, reproductive organs, and other tissues. Spontaneous and targeted Wnt7a mutations in mouse models resulted in abnormal limbs, defects in male and female reproductive tract organs, infertility, and defects in cerebellar axon remodeling. In zebrafish, wnt7aa mutants exhibited neurogenesis and angiogenesis defects in the central nervous system. In humans, recessive WNT7A missense and nonsense mutations resulted in severe limb and pelvic bone defects. Alterations in WNT7A expression correlated with multiple types of cancer.

• Publication year

  2025

• Venue

  Differentiation; research in biological diversity

• Publication date

  2025-08-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.diff.2025.100899PMID 40815867
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2024cited by this paper
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  2023cited by this paper
• Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders

  2022cited by this paper
• Wnt7a promotes the osteogenic differentiation of human mesenchymal stem cells

  2021cited by this paper
• Roles of Wnt7a in embryo development, tissue homeostasis, and human diseases

  2019cited by this paper
• The Zebrafish Information Network: new support for non-coding genes, richer Gene Ontology annotations and the Alliance of Genome Resources

  2018cited by this paper
• High expression of WNT7A predicts poor prognosis and promote tumor metastasis in pancreatic ductal adenocarcinoma

  2018cited by this paper
• Loss of Wnt7a expression correlates with tumor progression and poor prognosis in colorectal carcinoma.

  2018cited by this paper
• Santos syndrome is caused by mutation in the WNT7A gene

  2017cited by this paper
• A novel missense mutation, p.(R102W) in WNT7A causes Al-Awadi Raas-Rothschild syndrome in a fetus.

  2016cited by this paper
• Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development

  2015cited by this paper
• Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

  2015cited by this paper
• Lhx1 is required in Müllerian duct epithelium for uterine development.

  2014cited by this paper
• Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength

  2014cited by this paper
• Wnt7a Regulates Multiple Steps of Neurogenesis

  2013cited by this paper
• A report of two cases of Al-Awadi Raas-Rothschild syndrome (AARRS) supporting that "apparent" Phocomelia differentiates AARRS from Schinzel Phocomelia syndrome (SPS).

  2013cited by this paper
• Wnt7a treatment ameliorates muscular dystrophy

  2012cited by this paper
• Wnt/β-catenin signaling and disease.

  2012cited by this paper
• Alterations of the WNT7A Gene in Clear Cell Renal Cell Carcinomas

  2012cited by this paper
• WNT pathways and upper limb anomalies

  2011cited by this paper
• Al‐Awadi–Raas‐Rothschild (limb/pelvis/uterus–hypoplasia/aplasia) syndrome and WNT7A mutations: Genetic homogeneity and nosological delineation

  2011cited by this paper
• All four zebrafish Wnt7 genes are expressed during early brain development.

  2011cited by this paper
• A novel homozygous missense mutation (c.610G>A, p.Gly204Ser) in the WNT7A gene causes tetra‐amelia in two Saudi families

  2011cited by this paper
• Postnatal Deletion of Wnt7a Inhibits Uterine Gland Morphogenesis and Compromises Adult Fertility in Mice1

  2011cited by this paper
• Expression of Wnt Signaling Components during Xenopus Pronephros Development

  2011cited by this paper
• Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses

  2010cited by this paper
• A novel homozygous Arg222Trp missense mutation in WNT7A in two sisters with severe Al‐Awadi/Raas‐Rothschild/Schinzel phocomelia syndrome

  2010cited by this paper
• Congenital Duplication of the Palm Syndrome: Gene Analysis and the Molecular Basis of its Clinical Features

  2009cited by this paper
• Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain

  2009cited by this paper
• Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.

  2009cited by this paper
• Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

  2008cited by this paper
• Dermal condensation formation in the chick embryo: Requirement for integrin engagement and subsequent stabilization by a possible Notch/integrin interaction

  2007cited by this paper
• Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome.

  2006cited by this paper
• Diethylstilbestrol exposure in utero: a paradigm for mechanisms leading to adult disease.

  2005cited by this paper
• A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

  2003cited by this paper
• WNT7a induces E-cadherin in lung cancer cells

  2003cited by this paper
• Functional Characterization of WNT7A Signaling in PC12 Cells

  2003cited by this paper
• The Wnts

  2001cited by this paper
• Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.

  2000cited by this paper
• Human-mouse differences in the embryonic expression patterns of developmental control genes and disease genes.

  2000cited by this paper
• Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.

  1998cited by this paper
• Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract.

  1998cited by this paper
• Cancer risk in women exposed to diethylstilbestrol in utero.

  1998cited by this paper
• Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a

  1998cited by this paper
• Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation.

  1998cited by this paper
• The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene.

  1998cited by this paper
• WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons.

  1997cited by this paper
• Isolation, characterization and chromosomal assignment of the human WNT7A gene.

  1996cited by this paper
• Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

  1996cited by this paper
• Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb.

  1995cited by this paper
• Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

  1995cited by this paper
• Differential transformation of mammary epithelial cells by Wnt genes

  1994cited by this paper
• Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes.

  1993cited by this paper
• Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.

  1993cited by this paper
• Cloning and developmental expression in Xenopus laevis of seven additional members of the Wnt family.

  1992cited by this paper
• Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

  1992cited by this paper
• Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

  1990cited by this paper
• The genetics and morphology of two ‘luxoid’ mutants in the house mouse

  1964cited by this paper

• No citing papers are available for this paper.