Unraveling the genetic link: causal effects and PRS predictions of adiposity‐related health conditions in East Asian individuals

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Obesity

• Publication date

  2025-08-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/oby.24335PMID 40808477
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aminotransferases as causal factors for metabolic syndrome: A bidirectional Mendelian randomization study

  2024cited by this paper
• Your height affects your health: genetic determinants and health-related outcomes in Taiwan

  2022cited by this paper
• Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity

  2022cited by this paper
• The role of leptin and low testosterone in obesity

  2022cited by this paper
• Genomics and phenomics of body mass index reveals a complex disease network

  2022cited by this paper
• Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification

  2022cited by this paper
• Genome-wide study on 72,298 individuals in Korean biobank data for 76 traits

  2022cited by this paper
• Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies

  2021cited by this paper
• Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study

  2021cited by this paper
• A cross-population atlas of genetic associations for 220 human phenotypes

  2021cited by this paper
• Using Phecodes for Research with the Electronic Health Record: From PheWAS to PheRS.

  2021cited by this paper
• Obesity, Type 2 Diabetes, Lifestyle Factors and Risk of Gallstone Disease: A Mendelian Randomization Investigation.

  2021cited by this paper
• Adult obesity complications: challenges and clinical impact

  2020cited by this paper
• Computationally efficient whole-genome regression for quantitative and binary traits

  2020cited by this paper
• Causal Effects of Overall and Abdominal Obesity on Insulin Resistance and the Risk of Type 2 Diabetes Mellitus: A Two-Sample Mendelian Randomization Study

  2020cited by this paper
• From NAFLD to MAFLD: when pathophysiology succeeds

  2020cited by this paper
• Pathophysiological connections between gallstone disease, insulin resistance, and obesity

  2019cited by this paper
• Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization

  2019cited by this paper
• Obesity: global epidemiology and pathogenesis

  2019cited by this paper
• Combined Association of Body Mass Index and Alcohol Consumption With Biomarkers for Liver Injury and Incidence of Liver Disease

  2019cited by this paper
• Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study

  2019cited by this paper
• A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank.

  2019cited by this paper
• Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants

  2019cited by this paper
• The effect of liver enzymes on body composition: A Mendelian randomization study

  2019cited by this paper
• Exposing the Causal Effect of Body Mass Index on the Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study

  2019cited by this paper
• Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

  2018cited by this paper
• Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

  2018cited by this paper
• The MR-Base platform supports systematic causal inference across the human phenome

  2018cited by this paper
• Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry

  2018cited by this paper
• An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings

  2018cited by this paper
• The effect of liver enzymes on adiposity: a Mendelian randomization study

  2018cited by this paper
• Polygenic prediction via Bayesian regression and continuous shrinkage priors

  2018cited by this paper
• Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis

  2017cited by this paper
• Functional mapping and annotation of genetic associations with FUMA

  2017cited by this paper
• Free fatty acids profile among lean, overweight and obese non-alcoholic fatty liver disease patients: a case – control study

  2017cited by this paper
• Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project.

  2016cited by this paper
• MAGMA: Generalized Gene-Set Analysis of GWAS Data

  2015cited by this paper
• Personalized medicine in Type 2 Diabetes

  2014cited by this paper
• LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

  2014cited by this paper
• Leptin promotes the osteoblastic differentiation of vascular smooth muscle cells from female mice by increasing RANKL expression.

  2014cited by this paper
• Elevated body mass index as a causal risk factor for symptomatic gallstone disease: A Mendelian randomization study

  2013cited by this paper
• β-catenin regulates GnRH-induced FSHβ gene expression.

  2013cited by this paper
• The obesity epidemic. While America swallows $147 billion in obesity-related healthcare costs, physicians called on to confront the crisis.

  2013cited by this paper
• Vascular calcification and hypertension: Cause and effect

  2012cited by this paper
• Robust relationship inference in genome-wide association studies

  2010influential reference
• Hepatic insulin resistance directly promotes formation of cholesterol gallstones

  2008cited by this paper
• Leptin increases endothelin type A receptor levels in vascular smooth muscle cells.

  2008cited by this paper
• PLINK: a tool set for whole-genome association and population-based linkage analyses.

  2007influential reference
• A human hepatocellular in vitro model to investigate steatosis.

  2007cited by this paper

• No citing papers are available for this paper.