Synthesis and evaluation of lansiumamide B analogues to ameliorate acute lung injury by reducing oxidative stress and inflammation via Keap1/Nrf2/NF-κB pathway.

No abstract is available for this paper.

• Publication year

  2025

• Venue

  European journal of medicinal chemistry

• Publication date

  2025-08-08

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejmech.2025.118052PMID 40812070
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiology and pathophysiology of mucus and mucolytic use in critically ill patients

  2025cited by this paper
• Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury.

  2025cited by this paper
• Fiber-optic immunosensor based on a Fabry-Perot interferometer for single-molecule detection of biomarkers.

  2024cited by this paper
• Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

  2024cited by this paper
• DMSO-KOH mediated stereoselective synthesis of Z-enamides: an expeditious route to Z-enamide bearing natural products.

  2023cited by this paper
• Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

  2023cited by this paper
• Oxidative stress is the pivot for PM2.5-induced lung injury.

  2023cited by this paper
• Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury.

  2023cited by this paper
• Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

  2022cited by this paper
• Low-Molecular-Weight Synthetic Antioxidants: Classification, Pharmacological Profile, Effectiveness and Trends

  2022cited by this paper
• Redox regulation of the immune response

  2022cited by this paper
• Pathogenesis of pneumonia and acute lung injury.

  2022cited by this paper
• Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

  2021cited by this paper
• The role of NADPH oxidases in infectious and inflammatory diseases

  2021cited by this paper
• AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings

  2021cited by this paper
• Understanding oxidants and antioxidants: Classical team with new players.

  2020cited by this paper
• An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

  2020cited by this paper
• Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury

  2020cited by this paper
• Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA).

  2019cited by this paper
• Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?

  2019cited by this paper
• Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production.

  2019cited by this paper
• An aptamer nanopore-enabled microsensor for detection of theophylline.

  2018cited by this paper
• Macrophage Polarization Favors Epithelial Repair During Acute Respiratory Distress Syndrome*

  2018cited by this paper
• Synthesis and Fungicidal Activity of Lansiumamide A and B and Their Derivatives

  2018cited by this paper
• Guidelines for the Evaluation and Treatment of Pneumonia

  2018cited by this paper
• Mucins, Mucus, and Goblet Cells

  2017cited by this paper
• Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.

  2016cited by this paper
• The Keap1–Nrf2–ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

  2016cited by this paper
• Antibacterial activity of Lansiumamide B to tobacco bacterial wilt (Ralstonia solanacearum).

  2014cited by this paper
• The Fruits of Wampee Inhibit H2O2-Induced Apoptosis in PC12 Cells via the NF-κB Pathway and Regulation of Cellular Redox Status

  2014cited by this paper
• Lansiumamide B and SB-204900 isolated from Clausena lansium inhibit histamine and TNF-α release from RBL-2H3 cells

  2013cited by this paper
• Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

  2013cited by this paper
• Aptamers and Their Biological Applications

  2012cited by this paper
• Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.

  2011cited by this paper
• Antioxidant capacities and total phenolic contents of 62 fruits.

  2011cited by this paper
• AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

  2009cited by this paper
• Oxidative stress and redox regulation of lung inflammation in COPD

  2006cited by this paper
• Finding the target after screening the phenotype.

  2005cited by this paper
• Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases.

  2003cited by this paper
• Oxidative stress and regulation of glutathione in lung inflammation.

  2000cited by this paper
• Tracheal phenol red secretion, a new method for screening mucosecretolytic compounds.

  1984cited by this paper

• Scutellarin reduces apoptosis in R28 cells induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation through the Keap1/Nrf2/NF-κB pathway.

  2025cites this paper