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Food groups and micronutrients associated with chemotherapy-induced peripheral neuropathy in survivors of cancer post-neurotoxic treatment

K. Miller,S. Zick,R. Ploutz-Snyder,E. Ruiz-Narváez,R. Knoerl

Published 2025 in Supportive Care in Cancer

ABSTRACT

Determine the association of food group and micronutrient intake with chemotherapy-induced peripheral neuropathy (CIPN) among survivors of cancer. In this cross-sectional study, participants completed the PRO-CTACE™ numbness and tingling severity item and VioScreen™ Research Food Frequency Questionnaire to determine CIPN status and dietary intake, respectively. Separate covariate-adjusted linear, logistic, and ordered logistic regression models were used to calculate the mean food group and micronutrient amounts and the associations with CIPN status and severity. As a secondary analysis of prior research that was not powered to detect these associations, we considered p ≤ 0.10 as an indicator of relevance for future study. A total of 136 participants completed the surveys and questionnaires. Participants with greater daily intake of refined grains (OR = 2.05; 95% CI, 1.22, 3.46) and less intake of tomatoes (OR = 0.10; 95% CI, 0.10, 1.14), fish (OR = 0.21; 95% CI, 0.06, 0.75), eggs (OR = 0.06; 95% CI, 0.01, 0.34), and selenium (OR = 0.96; 95% CI, 0.92, 1.00) were associated with increased odds of having CIPN. The odds of experiencing worse CIPN severity increased with each additional serving of refined grains (OR = 1.66; 95% CI, 1.11, 2.48) and decreased with each extra serving of poultry (OR = 0.58; 95% CI, 0.31, 1.08), fish (OR = 0.18; 95% CI, 0.05, 0.61), egg (OR = 0.08; 95% CI, 0.02, 0.39), legumes (OR = 0.04; 95% CI, 0.00, 1.49), and selenium (OR = 0.96; 95% CI, 0.93, 1.35). There are meaningful intake differences between participants with and without CIPN. Further research is needed to establish a dietary intervention using the findings in a larger population.

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