Azanucleoside treatment leads to B-cell precursor acute lymphoblastic leukemia

Key Points • Treatment with ATC, an investigational azanucleoside, invariably leads to BCP-ALL in immunodeficient mice.• Two related mechanisms result in C>G mutation involving known cancer genes; the primary mechanism mutates 5-methyl-cytosine in a CpG context.

• Publication year

  2025

• Venue

  Blood neoplasia

• Publication date

  2025-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.bneo.2025.100161PMID 41158994PMCID 12555782
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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