Low‐Dose X‐Ray Radiation Enhances Intratumoral Accumulation and Antitumor Effects of Nanoscale Coordination Polymers via Neutrophil‐Mediated Trafficking

Nanoscale coordination polymers (NCPs) have emerged as a promising hybrid platform for drug delivery and cancer therapy. However, their potential in combination with radiotherapy (RT) remains largely unexplored. This study unveils a novel synergy between NCPs and RT, demonstrating a unique neutrophil‐mediated tumor trafficking mechanism. Following X‐ray irradiation, tumors recruit immune cells, particularly circulating neutrophils, which enhance NCP accumulation in the tumor by threefold. Notably, this effect is absent with other nanoparticles and operates independently of the enhanced permeability and retention effect. Immunostimulatory NCPs further leverage this mechanism to reshape the tumor microenvironment, promote immune cell infiltration, and enhance therapeutic efficacy. These findings underscore the potential of integrating NCP‐based nanomedicines with RT to provide a targeted and effective cancer treatment strategy with strong translational promise.

• Publication year

  2025

• Venue

  Advanced NanoBiomed Research

• Publication date

  2025-08-19

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1002/anbr.202500088
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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