The contributions of aquaporin‐4 to water exchange across the blood–brain barrier measured by filter‐exchange imaging

Zejun Wang,Shuyuan Tan,Keyu Lu,Qingcheng Li,Bingjie Jiao,Weiyun Li,Xuetao Wu,Lili Zhang,Linghui Zeng,Ruiliang Bai

Published 2025 in Magnetic Resonance in Medicine

ABSTRACT

Water exchange across the blood–brain barrier (WEXBBB) is a promising biomarker for assessing the blood–brain barrier (BBB) integrity. However, the physiological mechanisms governing WEXBBB remain unclear. This study was conducted to investigate the contribution of Na+/K+‐ATPase (NKA) on the luminal side of endothelial cells and aquaporin‐4 (AQP4) to WEXBBB.

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