Frequency-Dependent Modulation of Short-Term Neuronal Dynamics in the Female and Male Dorsal and Ventral Rat Hippocampus

Short-term synaptic plasticity (STSP) and short-term neuronal dynamics (STND) are fundamental properties of neural circuits, essential for information processing and brain function. Emerging evidence suggests that biological sex may influence these properties, yet sex-related differences in STSP and STND remain underexplored. This study investigates sex-specific differences in short-term synaptic plasticity (STSP) and neuronal dynamics (STND) along the dorsoventral axis of the rat hippocampus. Our findings reveal that both STSP and STND exhibit significant variation between female and male subjects. These differences are particularly pronounced in the ventral hippocampus, a region associated with affective and motivational processes. Given the role of short-term activity-dependent neuronal phenomena in modulating information processing and network function, these findings suggest potential functional implications for sex-specific cognitive and emotional regulation. The results highlight the importance of incorporating sex as a biological variable in studies of hippocampal physiology and its relation to behavior.

• Publication year

  2025

• Venue

  International Journal of Molecular Sciences

• Publication date

  2025-08-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms26178424PMID 40943345PMCID 12429153
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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